Horm Metab Res 2006; 38(12): 832-837
DOI: 10.1055/s-2006-956503
Original Clinical

© Georg Thieme Verlag KG Stuttgart · New York

Serum Lipids, Body Mass Index and Waist Circumference during Pubertal Development in Spanish Adolescents: The AVENA Study

J. R. Ruiz 1 , 2 , F. B. Ortega 1 , 2 , B. Tresaco 3 , J. Wärnberg 2 , 4 , J. L. Mesa 1 , M. González-Gross 1 , 5 , L. A. Moreno 3 , A. Marcos 4 , A. Gutiérrez 1 , M. J. Castillo 1 , The AVENA Study Group6
  • 1Departamento de Fisiología, Facultad de Medicina, Universidad de Granada, Granada, Spain
  • 2Unit for Preventive Nutrition, Department of Biosciences and Nutrition at NOVUM, Karolinska Institutet, Huddinge, Sweden
  • 3E. U. Ciencias de la Salud, Universidad de Zaragoza, Zaragoza, Spain
  • 4Grupo Inmunonutrición, Departamento de Nutrición y Metabolismo, Consejo Superior de Investigaciones Científicas, Madrid, Spain
  • 5Facultad de Ciencias de la Actividad Física y del Deporte, Universidad Politécnica de Madrid, Spain
  • 6AVENA Study Group: Coordinator: A. Marcos, Madrid; Main Investigators: M. J. Castillo, Granada; A. Marcos, Madrid; S. Zamora, Murcia; M. García Fuentes, Santander; M. Bueno, Zaragoza, Spain
    Granada: M. J. Castillo, M. D. Cano, R Sola (Biochemistry); A. Gutiérrez, J. L. Mesa, J. R. Ruiz (Physical fitness); M. Delgado, P. Tercedor, P. Chillón (Physical activity); F. B. Ortega, M. Martín, F. Carreño, G. V. Rodríguez, R. Castillo, F. Arellano (Collaborators); Universidad de Granada, 18071, Granada, Spain
    Madrid: A. Marcos, M. González-Gross, J. Wärnberg, S. Medina, F. Sánchez Muniz, E. Nova, A. Montero, B. de la Rosa, S. Gómez, S. Samartín, J. Romeo, R. Álvarez, (Coordination, immunology); A. Álvarez (Cytometric analysis); L. Barrios (Statistical analysis); A. Leyva, B. Payá (Psychological assessment); L. Martínez, E. Ramos, R. Ortiz, A. Urzanqui (Collaborators); Instituto de Nutrición y Bromatología, Consejo Superior de Investigaciones Científicas (CSIC), 28040 Madrid, Spain
    Murcia: S. Zamora, M. Garaulet, F. Pérez-Llamas, J. C. Baraza, J. F. Marín, F. Pérez de Heredia, M. A. Fernández, C. González, R. García, C. Torralba, E. Donat, E. Morales, M. D. García, J. A. Martínez, J. J. Hernández, A. Asensio, F. J. Plaza, M. J. López (Diet analysis); Dpto. Fisiología, Universidad de Murcia, 30100 Murcia, Spain
    Santander: M. García Fuentes, D. González-Lamuño, P. de Rufino, R. Pérez-Prieto, D. Fernández, T. Amigo (Genetic study); Dpto. Pediatría, Universidad de Cantabria, 19003 Santander, Spain
    Zaragoza: M. Bueno, L. A. Moreno, A. Sarriá, J. Fleta, G. Rodríguez, C. M. Gil, M. I. Mesana, J. A. Casajús, V. Blay, M. G. Blay (Anthropometric assessment); Escuela Universitaria de Ciencias de la Salud, Universidad de Zaragoza, 50009 Zaragoza, Spain
Further Information

Publication History

Received 6 April 2006

Accepted after revision 10 July 2006

Publication Date:
12 December 2006 (online)

Abstract

Aim: To describe the effects of chronological age and biological age (pubertal development) on serum lipid and lipoprotein levels, body mass index (BMI) and waist circumference in Spanish adolescents. Methods: A representative Spanish sample of 526 adolescents (254 males and 272 females), were studied. Total cholesterol (TC), high density lipoprotein cholesterol (HDLc), triglycerides, apolipoprotein A1 and B, and lipoprotein(a) were measured, and low density lipoprotein cholesterol (LDLc) was calculated. Additional measurements included BMI and waist circumference. Adolescents were classified according to chronological age, and pubertal development (also age of menarche in females). Results: In males, serum TC levels were lower at late puberty in comparison with early puberty, and serum LDLc levels were lower at late puberty in comparison with mid and early puberty. Serum HDLc levels were lower at mid puberty in comparison with early and late puberty. Serum TC and LDLc levels were not different when analyzed according to chronological age. In females, HDLc levels were lower at late puberty in comparison with early and mid puberty, but no differences were found when HDLc and the other studied lipid and lipoprotein variables were analyzed according to chronological age, or age of menarche. All the observed differences persisted after adjusting for BMI and waist circumference. In female adolescents, both BMI and waist circumference were higher at late puberty in comparison with early and mid puberty, while in males, BMI and waist circumference were different when analyzed according to chronological age. Conclusion: The results suggest that the assessment of pubertal development may provide additional valuable information when interpreting lipid profile and body fat in adolescents.

References

  • 1 Dennison BA, Kikuchi DA, Srinivasan SR, Webber LS, Berenson GS. Serum total cholesterol screening for the detection of elevated low-density lipoprotein in children and adolescents: The Bogalusa Heart Study.  Pediatrics. 1990;  85 472-479
  • 2 Porkka KVK, Viikari JSA, Rönnemaa T, Marniemi J, Akerblom HK. Age and gender specific serum lipid and apolipoprotein fractiles of Finnish children and young adults: The Cardiovascular Risk in Young Finns Study.  Acta Paediatr. 1994;  83 838-448
  • 3 Tell GS, Mittelmark MB, Vellar OD. Cholesterol, high density lipoprotein cholesterol and triglycerides during puberty: The Oslo Youth Study.  Am J Epidemiol. 1985;  122 750-761
  • 4 Cobbaert C, Deprost L, Mulder P, Rombaut K, Gijsels G, Kesteloot H. Pubertal serum lipoprotein (a) and its correlates in Belgian school-children.  Int J Epidemiol. 1995;  24 78-87
  • 5 Bertrais S, Balkau B, Charles MA, Vol S, Calvet C, Tichet J. Puberty-associated differences in total cholesterol and triglyceride levels according to sex in French children aged 10-13 years.  Ann Epidemiol. 2000;  10 316-323
  • 6 Kwiterovich PO, Barton BA, McMahon RP, Obarzanek E, Hunsberger S, Simons-Morton D. Effects of diet and sexual maturation on low-density lipoprotein cholesterol during puberty: The Dietary Intervention Study in Children (DISC).  Circulation. 1997;  96 2526-2533
  • 7 Preece MA. Evaluation of growth and development. In: Avner, ED, Barratt TM, Holliday MA, eds Pediatric Nephrology 3rd ed. Philadelphia, PA, Williams & Wilkins 1994: 37-396
  • 8 Mesa JL, Ruiz JR, Ortega FB, Warnberg J, González-Lamuño D, Moreno LA. Aerobic physical fitness in relation to blood lipids and fasting glycaemia in adolescents Influence of weight Status.  Nutr Metab Cardiovasc Dis. 2006;  16 285-293
  • 9 Mesa JL, Ortega FB, Ruiz JR, Castillo MJ, Tresaco B, Carreño F. Anthropometric determinants of a clustering of lipid-related atherogenesis risk factors in overweight and non-overweight adolescents Influence of cardiorespiratory fitness.  Ann Nutr Metab. , in press
  • 10 Berg G, Mesch V, Boero L, Sayegh F, Prada M, Royer M. Lipid and lipoprotein profile in menopausal transition Effects of hormones, age and fat distribution.  Horm Metab Res. 2004;  36 215-220
  • 11 González-Gross M, Castillo MJ, Moreno LA, Nova E, González-Lamuño D, Pérez-Llamas F. Alimentación y valoración del estado nutricional de los adolescentes españoles (Estudio AVENA) Evaluación de riesgos y propuesta de intervención. I. Descripción metodológica del proyecto.  Nutr Hosp. 2003;  18 15-28
  • 12 Moreno LA, Mesana MI, Fleta J, Ruiz JR, González-Gross M, Sarría A, Marcos A, Bueno M. AVENA Study Group . Overweight, obesity and body fat composition in Spanish adolescents The AVENA Study.  Ann Nut Metab. 2005;  49 71-76
  • 13 Ruiz JR, Ortega FB, Moreno LA, Warnberg J, Gutiérrez A, González-Gross, Cano MD, Gutiérrez A, Castillo MJ. Reference values for serum lipids and lipoproteins in Spanish adolescents. The AVENA study.  Soz Praventiv Med. 2006;  51 99-109
  • 14 Moreno LA, Joyanes M, Mesana MI, Gonzalez-Gross M, Gil CM, Sarria A, Gutierrez A, Garaulet M, Perez-Prieto R, Bueno M, Marcos A. AVENA Study Group . Harmonization of anthropometric measurements for a multicenter nutrition survey in Spanish adolescents.  Nutrition. 2003;  19 481-486
  • 15 Tanner JM, Whitehouse RH. Clinical longitudinal standards for height, weight, height velocity and stages of puberty.  Arch Dis Child. 1976;  51 170-179
  • 16 Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in serum, without use of the preparative ultracentrifuge.  Clin Chem. 1972;  18 499-502
  • 17 Morley R, Baker BA, Greene LC, Livingstone MB, Harland PS, Lucas A. Dietary fibre, exercise and serum lipids and lipoprotein cholesterols in 12 to 15 year olds.  Acta Paediatr. 1998;  87 1230-1234
  • 18 Berenson GS, Srinivasan SR, Cresanta JL, Foster TA, Webber LS. Dynamic changes of serum lipoproteins in children during adolescence and sexual maturation.  Am J Epidemiol. 1981;  113 157-170
  • 19 Dacou-Voutetakis C, Trichopoulou A, Papazissis G, Lagos P, Clontza D, Agathopoulos A. Serum cholesterol concentration in Greek pupils aged 9-18 years The effect of puberty.  Acta Paediatr Scand. 1981;  70 257-258
  • 20 Srinivasan SR, Freedman DS, Sundaram GS, Webber LS, Berenson GS. Racial (black-white) comparisons of the relationship of levels of endogenous sex hormones to serum lipoproteins during male adolescence: the Bogalusa Heart Study.  Circulation. 1986;  74 1226-1234
  • 21 Srinivasan SR, Wattigney W, Webber LS, Berenson GS. Race and gender differences in serum lipoproteins of children, adolescents, and young adults-Emergence of an adverse lipoprotein pattern in white males: The Bogalusa Heart Study.  Prev Med. 1991;  20 671-684
  • 22 Morrison JA, Barton BA, Biro FM, Sprecher DL. Sex hormones and the changes in adolescent male lipids: longitudinal studies in a biracial cohort.  J Pediatr. 2003;  142 637-642
  • 23 Remsberg KE, Demerath EW, Schubert CM, Chumlea WC, Sun SS, Siervogel RM. Early menarche and the development of cardiovascular disease risk factors in adolescent girls: the Fels Longitudinal Study.  J Clin Endocrinol Metab. 2005;  90 2718-2724
  • 24 Morrison JA, Laskarzewski PM, Rauh JL, Brookman R, Mellies M, Frazer M, Khoury P, deGroot I, Kelly K, Glueck CJ. Lipids, lipoproteins, and sexual maturation during adolescence: the Princeton maturation study.  Metabolism. 1979;  28 641-649
  • 25 Lamarche B, Tchernof S, Moorjani B, Cantin GR, Dagenais PJ, Lupien PJ. Small, dense low-density lipoprotein particles as a predictor of the risk of ischemic heart disease in men: prospective results from the Québec Cardiovascular Study.  Circulation. 1997;  95 69-75
  • 26 Glomset JA, Assmann G, Gjone E, Norum KR. Lecithin:cholesterol acyltransferase deficiency and fish-eye disease. In: Scriber CR, Beaudet AL, Sly WS, Valle D, eds. The Metabolic and Molecular Basis of Inherited Disease 7th ed. Vol. II New York: McGraw-Hill, Inc. 1995: 1993-1951
  • 27 Anber V, Griffin BA, McConnell M, Packard CJ, Shepherd J. Influence of plasma lipid and LDL-subfraction profile on the interaction between low density lipoprotein with human arterial wall proteoglycans.  Atherosclerosis. 1996;  124 261-271
  • 28 Rapkin AJ, Tsao JC, Turk N, Anderson M, Zeltzer LK. Relationships among Self-Rated Tanner Staging, Hormones, and Psychosocial Factors in Healthy Female Adolescents.  J Pediatr Adolesc Gynecol. 2006;  19 181-187
  • 29 Hoffman WH, Barbeau P, Litaker MS, Johnson MH, Howe CA, Gutin B. Tanner staging of secondary sexual characteristics and body composition, blood pressure, and insulin in black girls.  Obes Res. 2005;  13 2195-2201

Correspondence

Jonatan R. Ruiz

Departamento de Fisiología

Facultad de Medicina

Universidad de Granada

18012 Granada

Spain

Phone: +34/958/24 35 40

Fax: +34/958/24 90 15

Email: ruizj@ugr.es