Molekulare Bildgebung in der Neurologie

Zusammenfassung

Die molekulare Bildgebung stellt auch in der Neurologie und den Neurowissenschaften eine sich rasch entwickelnde, aufregende Technik dar, um Genomik und Proteomik über indirekte und direkte Marker quantitativ abbilden zu können. Hier spielt die nuklearmedizinische Bildgebung wegen ihres Tracerprinzips eine herausragende Rolle, da sie im Vergleich zu den anderen molekularen In-vivo-Bildgebungsverfahren über eine ausgezeichnete Sensitivität verfügt. Die aktuelle Entwicklung der molekularen Bildgebung in der Neurologie geht zunehmend weg von indirekten Markern der Gen- und Proteinexpression zur unmittelbaren Darstellung der molekularen Mechanismen. Der vorliegende Artikel soll einen kurzen Überblick über den Stand der molekularen Bildgebung in der Neurologie bieten und dabei insbesondere auf die klinisch relevanten Aspekte abzielen.

Abstract

Molecular imaging in neurology and neuroscience is a suspenseful and fast developing tool in order to quantitatively image genomics and proteomics by means of direct and indirect markers. Because of its high-sensitive tracer principle, nuclear medicine imaging has the pioneering task for the methodical progression of molecular imaging. The current development of molecular imaging in neurology changes from the use of indirect markers of gene and protein expression to the direct imaging of the molecular mechanisms. It is the aim of this article to give a short review on the status quo of molecular imaging in neurology with emphasis on clinically relevant aspects.

Schlüsselwörter

Genomik - Proteomik - Signaltransduktion - Gentherapie - Alzheimer - Parkinson - Gliome

Key words

genomics - proteomics - signal transduction - gene therapy - Alzheimer - Parkinson - glioma

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