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Synfacts 2006(10): 0995-0995
DOI: 10.1055/s-2006-949348
DOI: 10.1055/s-2006-949348
Synthesis of Heterocycles
© Georg Thieme Verlag Stuttgart · New York
Synthesis of Indolo-Fused Nitrogen Heterocycles
E. M. Beccalli*, G. Broggini, M. Martinelli, G. Paladino, E. Rossi
Università di Milano and Università dell’Insubria, Como, Italy
Further Information
Publication History
Publication Date:
21 September 2006 (online)
Significance
The synthesis of fused seven- to nine-membered heterocyclic ring indole derivatives by Pd-catalyzed intramolecular Heck-type cyclization is reported. The precursors are derived by standard amide bond forming reactions from readily available materials. The reactions proceed in modest to excellent yields. For the less reactive aryl bromides, microwave irradiation improved the yields of the cyclization reaction.