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Horm Metab Res 2006; 38(7): 447-451
DOI: 10.1055/s-2006-947842
Original Basic

© Georg Thieme Verlag KG Stuttgart · New York

Haplotypes in the Promoter Region of the ADIPOQ Gene are Associated with Increased Diabetes Risk in a German Caucasian Population

P. E. H. Schwarz 1 , S. Govindarajalu 1 , W. Towers 1 , 3 , U. Schwanebeck 2 , S. Fischer 1 , F. Vasseur 4 , S. R. Bornstein 1 , J. Schulze 1
  • 1III° Medical Clinic Department of Endocrinopathies and Metabolic Diseases
  • 2Department of Biometrics, Carl Gustav Carus Medical School, Dresden University of Technology, Dresden, Germany
  • 3Center for Genome Research, Potchefstroom University for CHE, Pretoria, South Africa
  • 4CNRS UMR 8090 and University Hospital of Lille, France
Further Information

Publication History

Received 29 March 2006

Accepted after revision 20 April 2006

Publication Date:
24 August 2006 (online)

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Abstract

Adiponectin, which is encoded by the ADIPOQ gene, has been shown to modulate insulin sensitivity and glucose homeostasis. Plasma adiponectin levels are decreased in type 2 diabetes and obesity. Genetic variations within the ADIPOQ gene are associated with decreased adiponectin hormone levels. To analyze specific single-nucleotide polymorphisms (SNPs) and their association with T2D, 365 German subjects with T2D and 323 control subjects were screened. Three common SNPs - +45T>G in exon 2, and 2 promoter variants SNPs -11391G>A and -11377C>G - were analyzed. We found that the variant allele of SNP -11391G>A was significantly more frequent in the diabetic patient group than in the control group (p=0.003). Carrying the haplotype of SNP -11391A and SNP -11377C was associated with a 1.50-fold (p=0.03) increase in diabetes risk. The combination of the A-C haplotype and the G-C haplotype was associated with significantly elevated diabetes risk (OR=2.82 (95% CI: 1.35-5.91), p=0.006) after correction for BMI and age. Our observations suggest that diploid combinations of haplotype in the adiponectin gene promoter region contribute to the genetic risk of T2D in individuals from a German Caucasian population.

Key words

Adiponectin - ADIPOQ - type 2 diabetes - haplotypes - promoter variants

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Correspondence

Dr. med. Peter Egbert Hermann SchwarzIII° 

Medical Clinic·Carl Gustav Carus Medical School·Dresden University of Technology

Fetscherstrasse 74·01307 Dresden·Germany

Phone: +49/351/458 27 15

Fax: +49/351/458 87 03

Email: pschwarz@rcs.urz.tu-dresden.de