Synthesis of 4-(Fmoc-aminoacyloxymethyl)phenoxyacetic Acids for Use in Solid-Phase Peptide Synthesis

Abstract

The synthesis of 4-(Fmoc-aminoacyloxymethyl)phen­oxyacetic acids was achieved in high yield by the reaction of Fmoc-amino acids with (4-iodomethylphenoxy)acetic acid 2-oxo-2-phenylethyl ester. The removal of the temporary protecting group, phenacyl ester, was effectively achieved by reductive cleavage with magnesium turnings.

Key words

solid-phase synthesis - magnesium - peptides

References

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20

Benzotriazol-1-yloxytripyrrolidinophosphonium hexafluorophosphate.