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Synthesis 2006(12): 1937-1939
DOI: 10.1055/s-2006-942376
DOI: 10.1055/s-2006-942376
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York
Strecker Reaction of Aldimines Catalyzed by a Nucleophilic N-Heterocyclic Carbene
Further Information
Received
15 December 2005
Publication Date:
05 May 2006 (online)
Publication History
Publication Date:
05 May 2006 (online)
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Abstract
The first method for Strecker reaction (cyanation of imines) of aldimines with TMSCN in the presence of N-heterocyclic carbene prepared from 1,3-bis(2,4,6-trimethylphenyl)imidazolium chloride and t-BuOK, as a nucleophilic catalyst, is described.
Key words
Strecker reaction - aldimine - N-heterocyclic carbene - imidazolium salt - cyanation
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