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DOI: 10.1055/s-2006-932453
Elucidation of the Biosynthetic Pathway Leading to the Complex Nonadride Phomoidride B
Publication History
Publication Date:
06 February 2006 (online)
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Abstract
In this Account we recall our studies into the biosynthesis of the complex fungal secondary metabolite phomoidride B (also known as CP-263,114). Our labeling studies revealed this natural product is produced by a remarkable dimerization of a sixteen-carbon anhydride. This unique biosynthetic pathway provides new opportunities in the area of combinatorial biosynthesis for the production of structurally novel unnatural products.
1 Introduction
1.1 Discovery and Classification of the Phomoidrides
1.2 Proposed Biosynthesis
2 Production of Phomoidrides A-D
2.1 A False Start
2.2 Classification of Phomoidride Producer
2.3 Regulation of Phomoidride Production
3 Labeling Studies with Small Molecule Precursors
4 Proving the C16+C16 Dimerization
5 Future Directions
Key words
biosynthesis - natural products - biomimetic synthesis - cyclizations - NMR
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