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Synfacts 2006(4): 0360-0360  
DOI: 10.1055/s-2006-932041
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Ambient Pressure Asymmetric Imine Hydrogenation

Contributor(s): Mark Lautens, Andrew Martins
A. Dervisi*, C. Carcedo, L-I. Ooi
Cardiff University, UK
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Publication History

Publication Date:
24 March 2006 (online)

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Significance

Using an Ir(I)-ddppm complex, a variety of aromatic imines could be hydrogenated to chiral secondary amines with excellent yields and very good enantioselectivities. The key aspect of these reactions is that they were performed at ambient temperatures and 1 atm of H2(g). Interestingly, increasing the pressure of H2(g) led to erosion of enantioselectivity.