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DOI: 10.1055/s-2006-931604
A New Cytotoxic Amide from the Stem Wood of Hibiscus tiliaceus
Publication History
Received: February 21, 2006
Accepted: March 28, 2006
Publication Date:
29 May 2006 (online)
Abstract
A new coumarin, hibiscusin, and a new amide, hibiscusamide, together with eleven known compounds including vanillic acid, p-hydroxybenzoic acid, syringic acid, p-hydroxybenzaldehyde, scopoletin, N-trans-feruloyltyramine, N-cis-feruloyltyramine, a mixture of β-sitosterol and stigmasterol, a mixture of β-sitostenone and stigmasta-4,22-dien-3-one were isolated from the stem wood of Hibiscus tiliaceus. The structures of these new compounds were determined through spectral analyses. Among the isolates, three compounds exhibited cytotoxicity (IC50 values < 4 μg/mL) against P-388 and/or HT-29 cell lines in vitro.
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Dr. J. J. Chen
Graduate Institute of Pharmaceutical Technology
Tajen University
Pingtung 907
Taiwan
Republic of China
Phone: +886-8-762-4002 ext. 332
Fax: +886-8-762-5308
Email: jjchen@mail.tajen.edu.tw
- www.thieme-connect.de/ejournals/toc/plantamedica