Semin Vasc Med 2005; 05(4): 387-398
DOI: 10.1055/s-2005-922485
Copyright © 2005 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Fibrin D-Dimer and Cardiovascular Risk

Gordon D.O Lowe1
  • 1Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom
Further Information

Publication History

Publication Date:
22 November 2005 (online)

ABSTRACT

Fibrin D-dimer, the most commonly used clinical assay for detection of coagulation activation and in vivo fibrin formation and lysis in circulating blood, has been associated with risks of cardiovascular diseases in studies published over the past 15 years. This review discusses, in turn, analytic and preanalytic considerations; associations with risk factors; and associations with coronary heart disease, atrial fibrillation, stroke and cerebrovascular disease, peripheral arterial disease, and venous thromboembolism. These associations suggest that activated coagulation and in vivo fibrin formation and lysis may play a role in arterial, intracardiac, and venous thromboembolism. The potential clinical utility of D-dimer in prediction of cardiovascular risk, in indicating patient groups for prophylactic anticoagulation and in monitoring of anticoagulation, requires further study. Harmonization of results from different assays would increase clinical utility.

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  • 130 Smith F B, Rumley A, Lee A J, Leng G C, Fowkes FGR, Lowe G D. Haemostatic factors and prediction of ischaemic heart disease and stroke in claudicants.  Br J Haematol. 1998;  100 758-763
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  • 135 Lowe G D. Prediction of postoperative venous thrombosis using haemostasis tests.  Int J Clin Lab Res. 1997;  27 153-157
  • 136 Palareti G, Legnani C, Cosmi B, Guazzaloca G, Pancani C, Coccheri S. Risk of venous thromboembolism recurrence: high negative predictive value of D-dimer performed after oral anticoagulation is stopped.  Thromb Haemost. 2002;  87 7-12
  • 137 Palareti G, Legnani C, Cosmi B et al.. Predictive value of D-dimer test for recurrent venous thromboembolism after anticoagulation withdrawal in subjects with a previous idiopathic event and in carriers of congenital thrombophilias.  Circulation. 2003;  108 313-318

Gordon D.O LoweM.D. F.R.C.P. 

Professor of Vascular Medicine, Division of Cardiovascular and Medical Sciences, University of Glasgow, Royal Infirmary, 3rd Floor, Queen Elizabeth Building

10 Alexandra Parade, Glasgow G31 2ER, United Kingdom

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