Synthesis of Novel Diethyl Indolylphosphonates and Tetraethyl Indolyl-1,1-bisphosphonates by Michael Addition

Abstract

As series of (1H-indol-3-yl)phosphonates and bisphosphonates as well as (1H-indol-1-yl)phosphonates and bisphosphonates was prepared via the Michael addition of substituted indoles with electron-deficient olefins like ethyl 2-(diethoxyphosphoryl)acrylate and tetraethyl ethenylidene-1,1-bisphosphonate. The chemoselectivity of the reaction is discussed.

Key words

indoles - phosphorous compounds - bisphosphonates - Michael additions - heterocycles

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