Planta Med 2006; 72(1): 62-64
DOI: 10.1055/s-2005-873140
Letter
© Georg Thieme Verlag KG Stuttgart · New York

A New Neuroprotective Compound of Ligustrum japonicum Leaves

Sang Hyun Sung1 , Eun Sil Kim2 , Ki Yong Lee2 , Mi Kyeong Lee2 , Young Choong Kim2
  • 1Elcom Science Co., Ltd., Seoul, Korea
  • 2College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul, Korea
Further Information

Publication History

Received: April 29, 2005

Accepted: May 30, 2005

Publication Date:
25 October 2005 (online)

Abstract

A new secoiridoid glycoside characterized as (8Z)-nuezhenide A (1) along with five known glycosides, (8E)-nuezhenide (2), (8Z)-nuezhenide (3), oleonuezhenide (4), osmanthuside B (5) and osmanthuside D (6), were isolated from the n-BuOH fraction of Ligustrum japonicum leaves. All six compounds significantly protected human neuroblastoma SH-SY5Y cells from 6-hydroxydopamine-induced neurotoxicity.

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Young Choong Kim

College of Pharmacy and Research Institute of Pharmaceutical Science

Seoul National University

San 56-1

Shillim-Dong

Kwanak-Gu

Seoul 151-742

Korea

Phone: +82-2-880-7842

Fax: +82-2-888-2933

Email: youngkim@snu.ac.kr