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DOI: 10.1055/s-2005-871282
© Georg Thieme Verlag KG Stuttgart · New York
Isolation of New Rotenoids from Boerhaavia diffusa and Evaluation of their Effect on Intestinal Motility
Publication History
Received: January 10, 2005
Accepted: April 20, 2005
Publication Date:
19 August 2005 (online)
Abstract
A bioassay-guided separation of a methanolic extract obtained from the roots of Boerhaavia diffusa L. (Nyctaginaceae) allowed us to isolate five compounds belonging to the class of rotenoids: the known boeravinone D (1), boeravinone E (2), compound 5 and two novel compounds that we have named boeravinone G (3) and boeravinone H (4). The structures of the new molecules have been determined on the basis of their HR-EI-MS, 1H- and 13C-NMR and 2D-NMR (HMQC, HMBC) data. All the isolated rotenoids have been evaluated for their effect on intestinal motility in vitro. Three of them (boeravinone G, boeravinone E and compound 5) exhibited spasmolytic activity. Preliminary structure-activity relationships have been established highlighting the effect of substitutions on rings B and D.
Key words
Nyctaginaceae - Boerhaavia diffusa - rotenoids - boeravinones - spasmolytic activity
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Francesca Borrelli
Dipartimento di Farmacologia Sperimentale
Università degli Studi di Napoli ”Federico II”
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