Endoscopy 2005; 37(12): 1165-1169
DOI: 10.1055/s-2005-870559
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Comparison of Capsule Endoscopy with Ileocolonoscopy for Detecting Small-Bowel Lesions in Patients with Seronegative Spondyloarthropathies

R.  Eliakim1 , A.  Karban1 , D.  Markovits1 , E.  Bardan2 , S.  Bar-Meir2 , D.  Abramowich3 , E.  Scapa3
  • 1Department of Gastroenterology and Rheumatology, Rambam Medical Center, Haifa, Israel
  • 2Department of Gastroenterology, Chaim Sheba Medical Center, Ramat-Gan, Israel
  • 3Asaf-Harofeh Medical Center, Zerifin, Israel
Further Information

Publication History

Submitted 31 July 2005

Accepted after revision 9 August 2005

Publication Date:
05 December 2005 (online)

Background and Study Aims: Patients with spondyloarthropathies are often found to have signs of small-bowel inflammation when examined by ileocolonoscopy. Because capsule endoscopy has been found to be superior to other endoscopic and radiological modalities in the detection of small-bowel inflammation, we aimed to compare the diagnostic yield of capsule endoscopy with that of ileocolonoscopy in the detection of small-bowel lesions in patients with spondyloarthropathies.
Patients and Methods: Twenty patients with documented seronegative peripheral arthritis, ankylosing spondylitis, or sacroiliitis, who had not taken nonsteroidal anti-inflammatory drugs (NSAIDs) in the preceding 2 months, participated in the study. The patients underwent capsule endoscopy, followed by ileocolonoscopy within 7 days, with blinded assessment of both examinations. Biopsies were taken when indicated and adverse events were monitored. Patients completed a questionnaire on their satisfaction with the two procedures.
Results: A total of 20 patients (11 men, 9 women; mean age 41 ± 13 years) with seronegative inflammatory spondyloarthropathies but without abdominal complaints completed the study. No adverse effects were reported and all the capsules were excreted. Of these 20 patients, 11 (55 %) had a normal small bowel on both examinations. Significant small-bowel findings (erythema, mucosal breaks, aphthous or linear ulcers, erosions) were detected by capsule endoscopy in six patients (30 %) and by ileocolonoscopy in only one patient. In addition, capsule endoscopy detected significant upper gastrointestinal pathology in 40 % of patients. The patients preferred capsule endoscopy to ileocolonoscopy.
Conclusions: Capsule endoscopy detected more small-bowel lesions than ileocolonoscopy, and provided additional potentially relevant information on upper gastrointestinal pathology in patients with spondyloarthropathies.

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R. Eliakim, M.D.

Department of Gastroenterology

Rambam Medical Center · Haifa 31096 · Israel·

Fax: +972-4-854-3058

Email: r_eliakim@rambam.health.gov.il