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Horm Metab Res 2005; 37(8): 505-509
DOI: 10.1055/s-2005-870318
Original Clinical
© Georg Thieme Verlag KG Stuttgart · New York

Relationship of Lipoprotein Lipase and Hepatic Triacylglycerol Lipase Activity to Serum Adiponectin Levels in Japanese Hyperlipidemic Men

J.  Kobayashi1 , M.  Kusunoki1 , Y.  Murase1 , M.  Kawashiri2 , T.  Higashikata2 , K.  Miwa2 , S.  Katsuda2 , M.  Takata2 , A.  Asano2 , A.  Nohara2 , A.  Inazu3 , H.  Mabuchi2
  • 1 Department of Lifestyle-related disease, Kanazawa University Graduate School of Medical Science, Japan
  • 2 Department of Internal Medicine, Kanazawa University Graduate School of Medical Science, Japan
  • 3 Kanazawa University, Faculty of Medicine, School of Health Science, Laboratory Sciences, Japan
Further Information

Publication History

Received 15 December 2004

Accepted after revision 8 March 2005

Publication Date:
01 September 2005 (online)

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Abstract

Objective: The aim of this study was to determine how lipoprotein lipase (LPL) and hepatic triacylglycerol lipase (HTGL) activity relate to serum adiponectin levels. Research design and methods: Fifty-five hyperlipidemic Japanese men were recruited for this study. LPL and HTGL activity in post-heparin plasma (PHP) was measured using Triton X-100 emulsified-[14C] triolein. The remaining activity in the presence of 1M NaCl was defined as HTGL activity. Serum adiponectin levels were determined by an enzyme-linked immunosorbent assay system. Result: LPL activity had a positive relationship with HDL2, but had no relation with HDL3, while HTGL had positive relationship with HDL3, but had no relationship with HDL2. LPL activity showed a positive relationship [r = 0.345, p = 0.010] to serum adiponectin levels, while and HTGL activity showed an inverse relationship [r = - 0.365 p = 0.006]. Multiple regression analysis with LPL and HTGL as dependent variables and age, BMI, serum adiponectin and the homeostasis model assessment of insulin resistance (HOMA-IR) as independent variables showed LPL and HTGL’s association to adiponectin did not persist after adjustments for these covariants. However, the association of LPL activity to HOMA-IR was found to persist after adjustments of age, BMI, and serum adiponectin. Conclusions: There was a co-linearity between insulin sensitivity and adiponectin as well as insulin sensitivity and LPL/HTGL activity.

Key words

Adiponectin · Hepatic triacylglycerol lipase · Lipoprotein lipase

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J. Kobayashi

Department of Lifestyle-related disease, Kanazawa University Graduate School of Medical Science

Takara-machi 13-1 · Kanazawa 920-8640 · Japan

Phone: +81-76-265-2268

Fax: +81-76-234-4246

Email: Junji@med.kanazawa-u.ac.jp