Planta Med 2005; 71(5): 412-415
DOI: 10.1055/s-2005-864134
Original Paper
Pharmacology
© Georg Thieme Verlag KG Stuttgart · New York

Inhibitory Effects of Acylated Kaempferol Glycosides from the Leaves of Cinnamomum kotoense on the Proliferation of Human Peripheral Blood Mononuclear Cells

Yuh-Chi Kuo1 , Chung-Kung Lu2 , Li-Wei Huang3 , Yueh-Hsiung Kuo4 , Chen Chang5 , Feng-Lin Hsu3 , Tzong-Huei Lee3
  • 1Department of Life Science, Fu-Jen Catholic University, Taipei, Taiwan
  • 2Planning and Research Department, National Museum of Marine Biology and Aquarium, Taipei, Taiwan
  • 3Graduate Institute of Pharmacognosy Science, Taipei Medical University, Taipei, Taiwan
  • 4Department of Chemistry, National Taiwan University, Taipei, Taiwan
  • 5Department of Botany, National Museum of Natural Science, Taichung, Taiwan
Further Information

Publication History

Received: June 22, 2004

Accepted: February 13, 2005

Publication Date:
01 June 2005 (online)

Abstract

A new chemical entity, namely kaempferol 3-O-α-L-[2-(Z)-p-coumaroyl-4-(E)-p-coumaroyl]rhamnopyranoside (1), and the known kaempferol 3-O-α-L-[2,4-di-(E)-p-coumaroyl]rhamnopyranoside (2) have been isolated from the methanolic extract of leaves of Cinnamomum kotoense. Structural elucidation of compounds 1 and 2 were achieved on the basis of spectroscopic analysis. The effects of compounds 1 and 2 on phytohemagglutinin (PHA) stimulated cell proliferation were studied towards human peripheral blood mononuclear cells (PBMC). The results indicated that compounds 1 and 2 suppressed PBMC proliferation induced by PHA with an IC50 value of 5.0 ± 1.3 and 6.0 ± 1.5 μM, respectively. Interleukin-2 production in activated PBMC inhibited by compounds 1 and 2 were in a concentration-dependent manner. Therefore, we suggested that compounds 1 and 2 in C. kotoense were likely the growth modulators for PBMC.

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Prof. Assist. Tzong-Huei Lee

Graduate Institute of Pharmacognosy Science

Taipei Medical University

Taipei

Taiwan 110

Republic of China

Phone: +886-2-2736-1661 ext. 6156

Fax: +886-2-2377-2265

Email: thlee@tmu.edu.tw