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DOI: 10.1055/s-2005-861382
Effect of Hormone Replacement Therapy on the Production of Bone-resorbing Cytokines by Peripheral Blood Cells in Postmenopausal Women
Publication History
Received 11 May 2004
Accepted after revision 16 September 2004
Publication Date:
13 June 2005 (online)
![](https://www.thieme-connect.de/media/hmr/200504/lookinside/thumbnails/10.1055-s-2005-861382-1.jpg)
Abstract
We studied the effects of hormone replacement therapy (HRT) with estrogen on postmenopausal changes in the production of bone-resorbing cytokines interleukin 1 beta (IL-1β) and tumor necrosis factor alpha (TNFα). Both cytokines were measured in the supernatants of lipopolysaccharide (LPS)-stimulated whole-blood cells from 72 untreated and 44 HRT-treated women by ELISA. The levels of IL-1β were significantly higher in women in their 40 s and 50 s and in postmenopausal women than in women in their teens, 20 s and 30 s, while the levels of TNFα did not show any changes related to age. Both levels in HRT-treated women were significantly lower than those in untreated women at almost every postmenopausal stage. In a prospective study, HRT induced significant declines in both levels. These results show that estrogen decreases the accelerated production of IL-1β and reduces the production of TNFα in postmenopausal women at each postmenopausal stage, even in late-postmenopausal women.
Key words
HRT - Postmenopause - IL-1β - TNFα - Whole-blood cells
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Hirokazu Uemura, M.D., PhD
Department of Obstetrics and Gynecology · University of Tokushima · School of Medicine
3-18-15 Kuramoto-cho · Tokushima · 770-8503 Japan
Phone: +81 (88) 633 71 77 ·
Fax: +81 (88) 631 26 30
Email: uemura@clin.med.tokushima-u.ac.jp