Three New Jatrophone-Type Diterpenoids from Euphorbia helioscopia

Abstract

Three new jatrophone-type diterpenoids, euphoheliosnoids A - C, together with two known related compounds, were isolated from the Chinese medicinal plant Euphorbia helioscopia L. The structures including relative stereochemistry of the new compounds were elucidated by spectroscopic methods and by comparison with known related compounds.

References

• 1 Yamamura S, Kosemura S, Ohba S, Ito M, Saito Y. The isolation and structures of euphoscopins A and B.  Tetrahedron Lett. 1981;  22 5315-8
• 2 Yamamura S, Shizuri Y, Kosemura S, Ohtsuka J, Tayama T, Ohba S, Ito M, Saito Y. Terada Y. Diterpenes from Euphorbia helioscopia .  Phytochemistry. 1989;  28 3421-36
• 3 Shizuri Y, Kosemura S, Ohtsuka J, Terada Y, Yamamura S, Ohba S, Ito M, Saito Y. Structural and conformational studies on euphornin and related diterpenes.  Tetrahedron Lett.. 1984;  25 1155-8
• 4 Kosemura S, Shizuri Y, Yamamura S. Isolation and structures of euphohelins, new toxic diterpenes from Euphorbia helioscopia L.  Bull Chem Soc Jpn. 1985;  58 3112-7
• 5 Zhao Y, Song G -Q, Guo Y -W. Rotundifolinol, a new 1,3-diarylpropan-2-ol from bark of Litsea rotundifolia var. oblongifolia .  J Asi Nat Prod Res. 2003;  5 273-7
• 6 Sun Y -Q, Guo Y -W. Gymnorrhizol, an unsual macrocyclic polydisulfide from the Chinese mangrove Bruguiera gymnorrhiza .  Tetrahedron Lett. 2004;  45 5533-5