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Planta Med 2004; 70(12): 1195-1200
DOI: 10.1055/s-2004-835851
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag KG Stuttgart · New York

Cytotoxic Xanthones and Biphenyls from the Root of Garcinia linii

Jih-Jung Chen1 , Ih-Sheng Chen2 , Chang-Yih Duh3
  • 1Department of Pharmacy, Tajen Institute of Technology, Pingtung, Taiwan, Republic of China
  • 2School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China
  • 3Institute of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China
This work was supported by a grant (NSC 91-2320-B-127-006) from the National Science Council of the Republic of China
Further Information

Publication History

Received: March 17, 2004

Accepted: June 26, 2004

Publication Date:
10 January 2005 (online)

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Abstract

Three new xanthones, linixanthones A - C, two new biphenyls, garcibiphenyls A and B, and a new benzopyran, garcibenzopyran, together with twelve known xanthones and a known biphenyl have been isolated from the root of Garcinia linii. The structures of these new compounds were determined through spectral analyses. Among the isolates, five compounds exhibited cytotoxicities (ED50 values < 4 μg/mL) against P-388 and HT-29 cell lines in vitro.

Key words

Garcinia linii - Guttiferae - root - linixanthones A - C - garcibiphenyls A - B - garcibenzopyran - cytotoxicity

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Dr. J. J. Chen

Department of Pharmacy

Tajen Institute of Technology

Pingtung

Taiwan 907

Republic of China

Phone: +886-8-7624002 ext 332

Fax: +886-8-7625308

Email: jjchen@ccsun.tajen.edu.tw

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