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Synthesis 2004(16): 2641-2644
DOI: 10.1055/s-2004-831232
DOI: 10.1055/s-2004-831232
PAPER
© Georg Thieme Verlag Stuttgart · New York
A Convenient Halogenation of α,β-Unsaturated Carbonyl Compounds with OXONE ® and Hydrohalic Acid (HBr, HCl)
Further Information
Received
17 June 2004
Publication Date:
11 October 2004 (online)
Publication History
Publication Date:
11 October 2004 (online)
![](https://www.thieme-connect.de/media/synthesis/200416/lookinside/thumbnails/10.1055-s-2004-831232-1.jpg)
Abstract
Mixtures of OXONE ® and hydrobromic acid or hydrochloric acid afford solutions of bromine or chlorine, respectively. α-Bromo- or α-chloro-α,β-unsaturated carbonyl compounds were prepared by addition of hydrobromic acid or hydrochloric acid to the mixture of α,β-unsaturated carbonyl compounds and OXONE ® in CH2Cl2 followed by treatment of Et3N in moderate to good yields.
Key words
halogenation - OXONE ® - hydrobromic acid - hydrochloric acid - α,β-unsaturated carbonyl compounds
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