Semin Liver Dis 2004; 24: 11-16
DOI: 10.1055/s-2004-828673
Published in 2004 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Hepatitis B Virus Kinetics and Mathematical Modeling

Alan S. Perelson1 , Ruy M. Ribeiro1 , 2
  • 1Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico
  • 2Department of Zoology, Oxford University, Oxford, United Kingdom
Further Information

Publication History

Publication Date:
11 June 2004 (online)

In this article, we review modeling and interpretation of kinetics data obtained from patients with chronic hepatitis B virus infection that has been treated with lamivudine, adefovir dipivoxil, and lamivudine plus famciclovir combination therapy.

REFERENCES

  • 1 Perelson A S. Modelling viral and immune system dynamics.  Nat Rev Immunol. 2002;  2 28-36
  • 2 Neumann A U, Lam N P, Dahari H et al.. Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy.  Science. 1998;  282 103-107
  • 3 Nowak M A, Bonhoeffer S, Hill A M et al.. Viral dynamics in hepatitis B virus infection.  Proc Natl Acad Sci USA. 1996;  93 4398-4402
  • 4 Tsiang M, Rooney J F, Toole J J, Gibbs C S. Biphasic clearance kinetics of hepatitis B virus from patients during adefovir dipivoxil therapy.  Hepatology. 1999;  29 1863-1869
  • 5 Lewin S R, Ribeiro R M, Walters T et al.. Analysis of hepatitis B viral load decline under potent therapy: complex decay profiles observed.  Hepatology. 2001;  34 1012-1020
  • 6 Zeuzem S, de Man R A, Honkoop P et al.. Dynamics of hepatitis B virus infection in vivo.  J Hepatol. 1997;  27 431-436
  • 7 Lau G K, Tsiang M, Hou J et al.. Combination therapy with lamivudine and famciclovir for chronic hepatitis B-infected Chinese patients: a viral dynamics study.  Hepatology. 2000;  32 394-399
  • 8 Wolters L M, Hansen B E, Niesters H G, de Man R A. Viral dynamics in chronic hepatitis B patients treated with lamivudine, lamivudine-famciclovir or lamivudine-ganciclovir.  Eur J Gastroenterol Hepatol. 2002;  14 1007-1011
  • 9 Wolters L M, Hansen B E, Niesters H G et al.. Viral dynamics during and after entecavir therapy in patients with chronic hepatitis B.  J Hepatol. 2002;  37 137-144
  • 10 Wolters L M, Hansen B E, Niesters H G et al.. The influence of baseline characteristics on viral dynamic parameters in chronic hepatitis B patients treated with lamivudine.  J Hepatol. 2002;  37 253-258
  • 11 Wolters L M, Hansen B E, Niesters H G et al.. Viral dynamics in chronic hepatitis B patients during lamivudine therapy.  Liver. 2002;  22 121-126
  • 12 Wei X, Ghosh S K, Taylor M E et al.. Viral dynamics in human immunodeficiency virus type 1 infection.  Nature. 1995;  373 117-122
  • 13 Perelson A S, Neumann A U, Markowitz M et al.. HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time.  Science. 1996;  271 1582-1586
  • 14 Ho D D, Neumann A U, Perelson A S et al.. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection.  Nature. 1995;  373 123-126
  • 15 Guidotti L G, Rochford R, Chung J et al.. Viral clearance without destruction of infected cells during acute HBV infection.  Science. 1999;  284 825-829
  • 16 Herrmann E, Lee J H, Marinos G et al.. Effect of ribavirin on hepatitis C viral kinetics in patients treated with pegylated interferon.  Hepatology. 2003;  37 1351-1358
  • 17 Perelson A S, Essunger P, Ho D D. Dynamics of HIV-1 and CD4+ lymphocytes in vivo.  AIDS. 1997;  11 S17-S24
  • 18 Whalley S A, Murray J M, Brown D et al.. Kinetics of acute hepatitis B virus infection in humans.  J Exp Med. 2001;  193 847-854
  • 19 Sato H, Orenstein J, Dimitrov D, Martin M. Cell-to-cell spread of HIV-1 occurs within minutes and may not involve the participation of virus particles.  Virology. 1992;  186 712-724

Alan S PerelsonPh.D. 

Theoretical Biology and Biophysics, MS K710, Los Alamos National Laboratory

Los Alamos, NM 87545

Email: asp@lanl.gov

    >