A Novel Cytotoxic Oxetane ent-Kauranoid from Isodon japonicus

Abstract

A novel 11,20 : 1,20-diepoxy-ent-kaurane diterpenoid, maoyecrystal I (1), was isolated from Isodon japonicus, and its structure was elucidated by spectroscopic methods and comparison with another new ent-kauranoid, rubescensin W (2) from Isodon rubescens var. taihangensis. The structure of 2 was determined by single crystal X-ray diffraction analysis. A bioassay of their cytotoxity against K562 cells showed that the oxetane group of 1 might be a bioactive moiety.

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