Planta Med 2004; 70(6): 540-550
DOI: 10.1055/s-2004-827155
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag KG Stuttgart · New York

Structure of Kaurane-Type Diterpenes from Parinari sprucei and their Potential Anticancer Activity

Alessandra Braca1 , Annahil Armenise1 , Ivano Morelli1 , Jeannette Mendez2 , Qiuwen Mi3 , Hee-Byung Chai3 , Steven M. Swanson3 , A. Douglas Kinghorn3 , Nunziatina  De Tommasi4
  • 1Dipartimento di Chimica Bioorganica e Biofarmacia, Università di Pisa, Pisa, Italy
  • 2Escuela de Quimica, Universidad Central de Venezuela, Caracas, Venezuela
  • 3Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA
  • 4Dipartimento di Scienze Farmaceutiche, Università di Salerno, Fisciano (SA), Italy
This work was supported in part by CNR (Consiglio Nazionale delle Ricerche, Roma) and by FONACIT (Fondo Nacional de Ciencia Tecnologia e Innovacion), and grant U19 CA 52 956 from the National Cancer Institute, NIH, Bethesda, MD, USA
Further Information

Publication History

Received: October 27, 2003

Accepted: March 7, 2004

Publication Date:
01 July 2004 (online)

Abstract

Twenty-three kaurane-type diterpenes 1 - 23, including twenty new natural products 1 - 20, have been isolated from the leaves of Parinari sprucei and their structures elucidated by spectroscopic and chemical analysis. The isolated compounds were tested for their cytotoxic activity towards a panel of cancer cell lines. Compounds 9 and 10 showed activity against all cell lines with ED50 values in the range of 10 - 20 μg/mL. The previously known 13-hydroxy-15-oxozoapatlin 21 was evaluated in an in vivo hollow fiber test, and found to be active with KB and LNCaP cells at the concentrations used.

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Prof. Nunziatina De Tommasi

Dipartimento di Scienze Farmaceutiche

Università di Salerno

Via Ponte Don Melillo

84084 Fisciano (SA)

Italy

Fax: +39-89-962828

Email: detommasi@unisa.it