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DOI: 10.1055/s-2004-818926
Kaurane-Type Diterpene Glycoside from the Stem Bark of Acanthopanax trifoliatus
This study was supported by a grant from the Korea-Vietnam international cooperation project by the Ministry of Science and Technology, in KoreaPublication History
Received: August 11, 2003
Accepted: November 29, 2003
Publication Date:
23 March 2004 (online)
![](https://www.thieme-connect.de/media/plantamedica/200403/lookinside/thumbnails/10.1055-s-2004-818926-1.jpg)
Abstract
A new diterpene glycoside, acantrifoside D (1), as well as three known diterpenes (2 - 4) were isolated from the stem bark of Acanthopanax trifoliatus from Vietnam. Based on 1D and 2D NMR spectroscopic data, their chemical structures were determined to be 16α,17-dihydroxy-ent-kauran-19-oic acid 16-O-β-D-glucopyranoside 19-O-β-D-glucopyranosyl ester (1), 16αH,17-isovalerate-ent-kauran-19-oic acid (2), ent-kaur-16-en-19-oic acid (3), and ent-pimara-8(14),15-dien-19-oic acid (4). Compounds 2 - 4 had strong inhibitory effects against COX-1 in an in vitro assay, with IC50 values of 0.21, 0.15 and 0.19 mM, respectively.
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Young Ho Kim Ph. D.
College of Pharmacy
Chungnam National University
Taejon 305-764
Korea
Phone: +82-42-821-5933
Fax: +82-42-823-6566
Email: yhk@cnu.ac.kr