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Semin Thromb Hemost 2003; 29(6): 653-660
DOI: 10.1055/s-2004-815636
Copyright © 2003 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Association between a Variant of the Glutathione S-Transferase P1 Gene (GSTP1) and Hypertension in Pregnancy in Japanese: Interaction with Parity, Age, and Genetic Factors

Kaori Ohta1 , Gen Kobashi2 , Akira Hata3 , Hideto Yamada4 , Hisanori Minakami4 , Seiichiro Fujimoto5 , Kiyotaro Kondo6 , Hidehiko Tamashiro1
  • 1Department of Health for Senior Citizens, Hokkaido University Graduate School of Medicine, Sapporo, Japan
  • 2Assistant Professor, Department of Health for Senior Citizens, Hokkaido University Graduate School of Medicine, Sapporo, Japan
  • 3Department of Public Health, Asahikawa Medical College, Asahikawa, Japan
  • 4Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
  • 5Nikko Memorial Hospital, Moraran, Japan
  • 6The University of the Air, Chiba, Japan
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Publication History

Publication Date:
13 January 2004 (online)

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ABSTRACT

Hypertension in pregnancy (HP), including preeclampsia (PE), is known to be a multifactorial disease. Recently, an Ile105Val variant of the glutathione S-transferase P1 gene (GSTP1) was shown to be associated with PE in The Netherlands. We therefore performed an association study of the Ile105Val variant comparing 131 patients with HP and 327 normal pregnant controls in Japan. We analyzed the data in the context of other risk factors before pregnancy. The frequency of the Ile/Val+Val/Val genotype of the GSTP1 was not significantly different between the HP (26%) patients and the controls (28%). However, in primiparous patients, the frequency was significantly different in elderly pregnancy (63% in severe HP vs. 18% in controls; P < 0.05), in the subgroup with the MM+MT genotypes of the angiotensinogen gene (50% in severe HP vs. 26% in controls; P < 0.05), and in the subgroup with the GA+AA genotypes of the endothelial nitric oxide synthase gene (42% in severe HP vs. 13% in controls; P < 0.05). These results suggest that this variant of the GSTP1 may play a role in the manifestation of HP together with other independently and/or synergistically acting factors, particularly in primiparous pregnancy.

KEYWORDS

Glutathione S-transferase P1 - preeclampsia - angiotensinogen - nitric oxide synthase - synergism

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