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Planta Med 2004; 70(1): 65-67
DOI: 10.1055/s-2004-815458
Letter
© Georg Thieme Verlag Stuttgart · New York

Isotamarixen - A New Antioxidant and Prolyl Endopeptidase-Inhibiting Triterpenoid from Tamarix hispida

Nurgul Sultanova2 , Talat Makhmoor1 , Amsha Yasin1 , Z. A. Abilov2 , V. B. Omurkamzinova2 ,  Atta-ur-Rahman1 , M. Iqbal Choudhary1
  • 1HEJ Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi, Pakistan
  • 2Department of Chemistry, Al-Farabi Kazakh State National University, Almaty, Kazakhstan
Further Information

Publication History

Received: January 31, 2003

Accepted: June 28, 2002

Publication Date:
06 February 2004 (online)

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Abstract

A new pentacyclic triterpenoid, 3α-(3′′,4′′-dihydroxy-trans-cinnamoyloxy)-D-friedoolean-14-en-28-oic acid (1) has been isolated along with two known compounds, rhamnocitrin (2) and isorhamnetin (3) from the aerial parts of Tamarix hispida Willd. Compound 1 was found to be a potent antioxidant. In addition, compounds 1 - 3 showed significant inhibitory activity against prolylendopeptidase (PEP).

References

  • 1 Sokolov L D. Rastitelnye Resursy USSR. USSR; L. Academ. Nauk 1986: 100-05
    Google Scholar
  • 2 Corbett R E, Cumming S D. Linchens and fungi, part X, 14 α-taraxerane. Journal of Chemical Society Perkin Transactions I 1972: 2827-9
    Google Scholar
  • 3 Razdan T K, Harkar S. Phytolaccanol and epiacetylaleuritoric acid, two triterpenoids from Phytolacca acinosa .  Phytochemistry. 1982;  21 2339-42
    CrossrefPubMedGoogle Scholar
  • 4 Sharma S K, Parmar V S. Novel constituents of Tamarix species.  Journal of Scientific and Industrial Research. 1998;  57 873-90
    PubMedGoogle Scholar
  • 5 Nawwar M AM, Sherbeiny A EA, Ansari M AE. Plant constituents of Tamarix aphylla flowers (Tamaricaceae).  Experientia. 1975;  31 1118
    PubMedGoogle Scholar
  • 6 Sissi H IE, Nawwar M AM, Saleh N AM. Plant constituents of Tamarix nilotica leaves (Tamaricaceae).  Experientia. 1973;  29 1064
    PubMedGoogle Scholar
  • 7 Noor A K, Kamil M, Ilias M. Constituents of Tamarix dioica Roxb. (Tamariscineae).  Indian J Chem. 1979;  18B 390
    PubMedGoogle Scholar
  • 8 Kimura K I, Kanou F, Yamashita Y, Yoshimoto T. Prolyl endopeptidase inhibitors derived from Actinomycetes.  Bioscience Biotechnology Biochemistry. 1997;  61 1754-6
    CrossrefPubMedGoogle Scholar
  • 9 Fan W, Tezuka Y, Komatsu K, Namba T, Kadota S. Prolyl endopeptidase inhibitors from the underground part of Rhodiola sacra S. H. Fu.  Biological & Pharmaceutical Bull. 1999;  22 157-61
    PubMedGoogle Scholar
  • 10 Toid K, Shinoda M, Miyazaki A. A novel prolyl endopeptidase inhibitor, JTP-4819, its behavioral and neurochemical properties for the treatment of Alzheimer’s disease.  Neuroscience. 1998;  9 17-29
    PubMedGoogle Scholar
  • 11 Lee H J, Song K S. Kynapcin-12, A new p-terphenyl derivative from Polyozellus multiplex, inhibits prolyl endopeptidase.  The Journal of Antibiotics (Tokyo). 2000;  53 714-9
    PubMedGoogle Scholar
  • 12 Lee S K, Zakaria H, Chung H, Luyengi L, Gamez E JC, Mehta R J, Kinghorn D, Pezzuto J M. Evaluation of the antioxidant potential of natural products.  Combinatorial Chemistry and High Throughput Screening. 1998;  1 35-46
    PubMedGoogle Scholar
  • 13 Soares J R, Dinis T CP, Cunha A P, Almeida L M. Antioxidant activities of some extracts of Thymus zygis .  Free Rad Res. 1997;  26 469-78
    PubMedGoogle Scholar
  • 14 Yoshimoto T, Walter R, Tsuru D. Proline-specific endopeptidase from Flavobacterium .  Journal of Biological Chemistry. 1980;  255 4786-92
    PubMedGoogle Scholar

Prof. M. Iqbal Choudhary

HEJ Research Institute of Chemistry

University of Karachi

Karachi-75270

Pakistan

Fax: +9221 9243190, 9243191

Email: hej@cyber.net.pk

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