Planta Med 2004; 70(1): 34-38
DOI: 10.1055/s-2004-815452
Original Paper
Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Flavonoids and a Sesquiterpene Lactone from Tanacetum microphyllum Inhibit Anti-Inflammatory Mediators in LPS-Stimulated Mouse Peritoneal Macrophages

María José Abad1 , Paulina Bermejo1 , María Alvarez1 , José Antonio Guerra1 , Ana María Silván1 , Angel Maria Villar1
  • 1Department of Pharmacology, Faculty of Pharmacy, University Complutense, Madrid, Spain
Further Information

Publication History

Received: June 5, 2003

Accepted: October 3, 2003

Publication Date:
06 February 2004 (online)

Abstract

In our ongoing research into anti-inflammatory compounds from Tanacetum microphyllum, four naturally occurring flavonoids (santin, ermanin, centaureidin and 5,3′-dihydroxy-4′-methoxy-7-methoxycarbonylflavonol) and one sesquiterpene lactone (hydroxyachillin) isolated from this plant, were evaluated as potential inhibitors of some macrophage functions involved in the inflammatory process. These five compounds significantly inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO) and prostaglandin E2 (PGE2) in a concentration-dependent manner. In the tumour necrosis factor-α (TNF-α) assay, only centaureidin and hydroxyachillin significantly inhibited the accumulation of TNF-α. These results indicate that these compounds may contribute to the anti-inflammatory properties of T. microphyllum.

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Dr. María José Abad Martínez

Department of Pharmacology

Faculty of Pharmacy

University Complutense

28040 Madrid

Spain

Fax: +34-1-3941726

Email: mjabad@farm.ucm.es