Planta Med 2003; 69(11): 1036-1040
DOI: 10.1055/s-2003-45152
Original Paper
Natural Product Chemsitry
© Georg Thieme Verlag Stuttgart · New York

Three New Triterpenoid Saponins from Ixeris sonchifolia and their Cytotoxic Activity

Xi-Zhi Feng1 , Mei Dong2 , Zhi-Jie Gao1 , Sui-Xu Xu3
  • 1Department of Chemistry, University of Virginia, Charlottesville, Virginia, USA
  • 2Department of Cell Biology, Neurobiology, and Anatomy, University of Cincinnati, Ohio, USA
  • 3Department of Natural Product Chemistry, Shenyang Pharmaceutical University, Shenyang, P. R. China
Further Information

Publication History

Received: May 13, 2003

Accepted: August 16, 2003

Publication Date:
09 January 2004 (online)

Abstract

Bioassay-guided fractionation of an active n-BuOH extract of the whole plant of Ixeris sonchifolia, using a cytotoxicity assay, resulted in the isolation of three new triterpenoid saponins, ixeris saponins A (1), B (2), and C (3). On the basis of chemical evidence and extensive spectral studies, their structures were established as echinocystic acid 3-O-β-D-glucopyranosyl(1→3)-β-D-glucopyranosyl(1→3)-α-L-arabinopyranoside (1), 3-O-{bis[β-D-glucopyranosyl(1→2 and 1→3)-α-L-arabinopyranosyl]}echinocystic acid 28-O-β-D-glucopyranosyl ester (2), and 3-O-[β-D-glucopyranosyl(1→3)-β-D-glucopyranosyl(1→3)-α-L-arabinopyranosyl]-16α, 23-dihydroxyolean-12-ene 28-O-β-D-glucopyranosyl ester (3). Compounds 2 and 3 showed significant cytotoxicity against cancer cell lines A375, L929, and HeLa with IC50 values ranging from 8.83 μM to 15.83 μM, while compound 1 was inactive against these three cell lines.

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Dr. Mei Dong

Department of Cell Biology, Neurobiology, and Anatomy

University of Cincinnati

Cincinnati

Ohio 45267

USA

Fax: +1-513-558-2445

Email: dongmi@mail.uc.edu