Licorice Consumption and Serum Testosterone in Healthy Man

D. Armanini; G. Bonanni; M. J. Mattarello; C. Fiore; P. Sartorato; M. Palermo

doi:10.1055/s-2003-42724

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Exp Clin Endocrinol Diabetes 2003; 111(6): 341-343
DOI: 10.1055/s-2003-42724

Article

J. A. Barth Verlag in Georg Thieme Verlag Stuttgart · New York

Licorice Consumption and Serum Testosterone in Healthy Man

D. Armanini¹ , G. Bonanni¹ , M. J. Mattarello¹ , C. Fiore¹ , P. Sartorato¹ , M. Palermo²

¹Department of Medical and Surgical Sciences - Endocrinology, University of Padua, Padua, Italy
²Endocrinology, University of Sassari, Sassari, Italy

Further Information

Publication History

Received: February 10, 2003 First decision: March 17, 2003

Accepted: March 22, 2003

Publication Date:
01 October 2003 (online)

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Abstract

We have previously found that licorice can reduce serum testosterone in healthy men. These results were not confirmed in another study, where the same amounts of licorice did not decrease salivary testosterone values. In the actual study we treated more cases with the same amount of licorice and reproduced our previous data. The mean testosterone values decreased by 26 % after one week of treatment (p < 0.01). There was also a significant increase in 17-OHP and LH concentrations and a slight, but not significant decrease in free testosterone. Licorice treatment, in addition, did not affect the response of testosterone and 17-OHP to stimulation with β-HCG.

Key words

Licorice - glycyrrhetinic acid - total testosterone - free testosterone

References

1 Armanini D, Bonanni G, Palermo M. Reduction of serum testosterone in men by licorice. N Engl J Med. 1999; 341 1158

Crossref PubMed Search in Google Scholar
2 Armanini D, Fiore C, Mattarello M J, Bielenberg J, Palermo M. History of the endocrine effects of licorice. Exp Clin Endocrinol Diabetes. 2002; 110 1-5

PubMed Search in Google Scholar
3 Armanini D, Lewicka S, Pratesi C, Scali M, Zennaro M C, Zovato S, Gottardo C, Simoncini M, Spigariol A, Zampollo V. Further studies on the mechanism of the mineralocorticoid action of licorice in humans. J Endocrinol Invest. 1996; 19 624-629

PubMed Search in Google Scholar
4 Bernardi M, D'Intino P, Trevisani F, Cantelli-Forti G I, Raggi M A, Turchetto E, Gasbarrini G. Effects of prolonged ingestion of graded doses of licorice by healthy volunteers. Life Science. 1994; 55 863

Crossref PubMed Search in Google Scholar
5 Farese R V, Biglieri E G, Shackleton C HL, Irony I, Gomez-Fontes R. Licorice-induced hypermineralocorticoidism. New Engl J Med. 1991; 325 1225-1227

PubMed Search in Google Scholar
6 Funder J W, Pearce P T, Smith R, Smith A. Mineralocorticoid action: target tissue specificity is enzyme not receptor mediated. Science. 1988; 242 583-585

Crossref PubMed Search in Google Scholar
7 Ge R S, Gao H B, Nacharaju V L, Gunsalus G L, Hardy M P. Identification of a kinetically distinct activity of 11β- hydroxysteroid dehydrogenase in rat Leydig cells. Endocrinology. 1996; 138 2435-2442

PubMed Search in Google Scholar
8 Hardy M P, Ganjam V K. Stress, 11 beta-HSD, and Leydig cell function. J Androl. 1997; 18 475-479

PubMed Search in Google Scholar
9 Josephs R A, Guinn J S, Harper M L, Askari F. Liquorice consumption and salivary testosterone concentrations. Lancet. 2001; 358 1613-1614

Crossref PubMed Search in Google Scholar
10 Leckie C M, Wellberg L A, Seckl J R. 11 beta-hydroxysteroid dehydrogenase is a predominant reductase in intact rat Leydig cells. J Endocrinol. 1998; 159 233-238

PubMed Search in Google Scholar
11 Monder C, Hardy M P, Blanchard R J, Blanchard D C. Comparative aspects of 11β-hydroxysteroid dehydrogenase. Testicular 11βhydroxysteroid-dehydrogenase. Development of a model for the mediation of Leydig cells function by corticosteroids. Steroids. 1994; 59 69-73

Crossref PubMed Search in Google Scholar
12 Palermo M, Gomez-Sanchez C, Roitman E, Schackleton C HL. Quantitation of cortisol 3-oxo-4-ene steroids in urine using gas chromatography/mass spectrometry with stable isotope-labeled internal standars. Steroids. 1996; 61 583-589

Crossref PubMed Search in Google Scholar
13 Sakamoto K, Wakabayashi K. Inhibitory effect of glycyrrhetinic acid on testosterone production in rat gonads. Endocrinol Jpn. 1988; 35 333-342

Crossref PubMed Search in Google Scholar
14 Stewart P M, Krozowski Z S. 11 Beta-hydroxysteroid dehydrogenase. Vitam Horm. 1999; 57 249-324

PubMed Search in Google Scholar
15 Takeuchi T, Nishii O, Okamura T, Yaginuma T. Effect of paeoniflorin, glycyrrhizin and glycyrrhetinic acid on ovarian androgen production. Am J Chinese Med. 1991; 19 73-78

Crossref PubMed Search in Google Scholar
16 Tamaya T, Sato S, Okada H. Possible mechanisms of steroid action of the plant herb extracts glycyrrhizin, glycyrrhetinic acid, and paeoniflorin: inhibition by plant herb extracts of steroid protein binding in the rabbit. Am J Obstet Gynecol. 1986; 155 1134-1139

PubMed Search in Google Scholar
17 Wang G M, Ge R S, Latif S A, Morris D J, Hardy M P. Expression of 11 beta-hydroxylase in rat Leydig cells. Endocrinology. 2002; 143 621-626

Crossref PubMed Search in Google Scholar
18 Yaginuma T, Izumi R, Yasui H, Arai T, Kawabata M. Effect of traditional herbal medicine on serum testosterone levels and its induction of regular ovulation in hyperandrogenic and oligomenorrheic women. Acta Obst Gynaec Jpn. 1982; 34 939-944

PubMed Search in Google Scholar

Prof. Decio Armanini

Department of Medical and Surgical Science - Endocrinology
University of Padua

Via Ospedale 105

35100 Padua

Italy

Phone: 0039049-8213023

Fax: 0 03 90 49-65 73 91

Email: decio.armanini@unipd.it