Sesquiterpenes and Other Constituents from the Aerial Parts of Inula japonica

Chao Yang; Chun-Ming Wang; Zhong-Jian Jia

doi:10.1055/s-2003-41123

Planta Medica, Inhaltsverzeichnis

Planta Med 2003; 69(7): 662-666
DOI: 10.1055/s-2003-41123

Original Paper

Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

Sesquiterpenes and Other Constituents from the Aerial Parts of Inula japonica

Chao Yang¹ , Chun-Ming Wang¹ , Zhong-Jian Jia¹

¹Department of Chemistry, National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, People's Republic of China

This work was supported by the National Natural Science Foundation of China NO. 29972017.

Abstract

Three new sesquiterpenes, 1β-hydroxy-8β-acetoxycostic acid methyl ester, 1β-hydroxy-8β-acetoxyisocostic acid methyl ester and 1β-hydroxy-4α,11α-eudesma-5-en-12,8β-olide, along with fourteen known compounds were isolated from the aerial parts of Inula japonica. The structures of these new compounds were elucidated by spectroscopic methods (IR, EIMS, HRMS, 1D and 2D NMR). 1,6α-dihydroxy-4αH-1,10-secoeudesma-5(10),11(13)-dien-12,8β-olide exhibited appreciable cytotoxic activity against cultured SMMC-7721 (human hepatoma cell) and HO-8910 (human ovarian carcinoma cell) with IC₅₀ values of 52.22 and 21.32 μg/mL, while 5αH-eudesma-4(15),11(13)-dien-12,8β-olide showed remarkable cytotoxic activity against cultured SMMC-7721 and HO-8910 with IC₅₀ values of 6.21 and 5.28 μg/mL, respectively.

Key words

Inula japonica - Compositae - sesquiterpene - eudesmane - cytotoxic activity

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Referenzen

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Prof. Zhong-Jian Jia

Department of Chemistry

Lanzhou University

Lanzhou

Gansu 730000

Peoples Republic of China

Fax: +86-0931-8912582

eMail: Jiazj@lzu.edu.cn