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Synlett 2003(4): 0473-0476
DOI: 10.1055/s-2003-37520
DOI: 10.1055/s-2003-37520
LETTER
© Georg Thieme Verlag Stuttgart · New York
Removable Phosphine Reagents for the Mitsunobu Reaction
Further Information
Received
26 November 2002
Publication Date:
26 February 2003 (online)
Publication History
Publication Date:
26 February 2003 (online)
Abstract
We have developed a novel triphenylphosphine replacement for the Mitsunobu reaction. We have demonstrated that 4-diphenylphosphanyl-benzoic acid 2-trimethylsilanyl-ethyl ester (DPPBE) is an efficient reagent and greatly facilitates the isolation of the desired product.
Key words
Mitsunobu reaction - triphenylphosphine - 4-diphenylphosphanyl-benzoic acid 2-trimethylsilanyl-ethyl ester (DPPBE)
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References
Phosphoric acid (85%) was used as an external reference.