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J Reconstr Microsurg 2003; 19(1): 017-020
DOI: 10.1055/s-2003-37186
Copyright © 2003 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1 (212) 584-4662

Nerve Anastomosis with Glue: Comparative Histologic Study of Fibrin and Cyanoacrylate Glue

K. Wieken1 , K. Angioi-Duprez2 , A. Lim3 , L. Marchal4 , M. Merle1
  • 1European Hand Institute, Maxéville-Nancy, France
  • 2Laboratoire d'Anatomie pathologique, Faculté de Médecine de Nancy, Vandoeuvre, France
  • 3National University Hospital, Singapore
  • 4Laboratoire de Microscopie Electronique, Faculté de Médecine de Nancy, Vandoeuvre, France
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Publication History

Publication Date:
12 February 2003 (online)

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ABSTRACT

The authors report the results of a comparative experimental nerve study, using a biologic tissue glue (fibrin) and a synthetic glue (2-cyanoacrylate) in a rat model. A tension-free repair is necessary with the use of fibrin glue, or gapping may occur, thus limiting the use of the agent in promoting re-neurotization. In addition, the human origin of fibrin and thrombin allow for the possibility of viral transmission. The aim of the study was to verify if the synthetic glue is a viable alternative, or whether it causes cellular and tissue lesions. Their main finding was that the cyanoacrylate causes a foreign-body inflammatory reaction and retractile fibrosis, often reducing the nerve diameter up to two-thirds. Cyanoacrylate glue is thus not recommended for peripheral nerve repair.

KEYWORD

Nerve repair - cyanocrylate - glue - fibrin

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