Semin Respir Crit Care Med 2002; 23(6): 549-554
DOI: 10.1055/s-2002-36519
Copyright © 2002 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Sinonasal Sarcoidosis: Diagnosis and Management

Thomas A. Tami
  • Department of Otolaryngology, University of Cincinnati College of Medicine, Cincinnati, Ohio
Further Information

Publication History

Publication Date:
07 January 2003 (online)

ABSTRACT

Sinonasal sarcoidosis is a fairly uncommon, yet clinically challenging, manifestation of this systemic disease. The diagnosis is often difficult to establish, treatment options are often unclear, and ultimate clinical responses can be quite variable. This article discusses the varied clinical presentations of this unusual nasal inflammatory process, as well as various treatment options, from simple local nasal hygiene measures to more aggressive systemic therapy. Although the role of surgical intervention is controversial, a simple review of some of the indications for surgery in these patients helps to clarify this somewhat cloudy clinical area. Aggressive clinical management in conjunction with long-term surveillance can often produce dramatic clinical responses for these difficult patients with sarcoidosis in the sinonasal area.

REFERENCES

  • 1 McCaffrey T V, McDonald T J. Sarcoidosis of the nose and paranasal sinuses.  Laryngoscope . 1983;  93 1281-1284
  • 2 Zeitlin J F, Tami T A, Baughman R, Winget D. Nasal and sinus manifestations of sarcoidosis.  Am J Rhinol . 2000;  14 157-161
  • 3 Fergie N, Jones N S, Havlat M F. The nasal manifestations of sarcoidosis: a review and report of eight cases.  J Laryngol Otol . 1999;  113 893-898
  • 4 deShazo R D, O'Brien M M, Justice W K, Pitcock J. Diagnostic criteria for sarcoidosis of the sinuses.  J Allergy Clin Immunol . 1999;  103(5 Pt 1) 789-795
  • 5 Lindeboom J A, van den Akker P H. Sinusitis as the first indication of sarcoidosis an incidental finding in a patient with presumed ``odontogenic'' sinusitis: case report.  Br J Oral Maxillofac Surg . 2000;  38 277-279
  • 6 Kieff D A, Boey H, Schaefer P W, Goodman M, Joseph M P. Isolated neurosarcoidosis presenting as anosmia and visual changes.  Otolaryngol Head Neck Surg . 1997;  117(suppl) S183-S186
  • 7 Milgrim L M, Cohen A F. Nonpulmonary sinonasal sarcoidosis with intracranial invasion.  Otolaryngol Head Neck Surg . 1996;  114 162-165
  • 8 Mazziotti S, Gaeta M, Blandino A, Vinci S, Pandolfo I. Perineural spread in a case of sinonasal sarcoidosis: case report.  Am J Neuroradiol . 2001;  22 1207-1208
  • 9 Hasni S A, Gruber B L. Sarcoidosis presenting as necrotizing sinus destruction mimicking Wegener's granulomatosis.  J Rheumatol . 2000;  27 512-514
  • 10 Wong R J, Gliklich R E, Rubin P A, Goodman M. Bilateral nasolacrimal duct obstruction managed with endoscopic techniques.  Arch Otolaryngol Head Neck Surg . 1998;  124 703-706
  • 11 Krespi Y P, Kuriloff D B, Aner M. Sarcoidosis of the sinonasal tract: a new staging system.  Otolaryngol Head Neck Surg . 1995;  112 221-227
  • 12 Lee J B, Koblenzer P S. Disfiguring cutaneous manifestation of sarcoidosis treated with thalidomide: a case report.  J Am Acad Dermatol . 1998;  39(5 pt 2) 835-838
  • 13 Gold S M, Tami T A. Role of middle meatus aspiration culture in the diagnosis of chronic sinusitis.  Laryngoscope . 1997;  107(12 pt 1) 1586-1589
  • 14 Marks S C, Goodman R S. Surgical management of nasal and sinus sarcoidosis.  Otolaryngol Head Neck Surg . 1998;  118 856-858
    >