Effect of Abietane Diterpenes from Plectranthus grandidentatus on the Growth of Human Cancer Cell Lines

Abstract

Five known abietane diterpenes, fatty acid esters of 7α-acyloxy-6β-hydroxyroyleanone (1), grandidone A (2), 7α-acetoxy-6β-hydroxyroyleanone (3), 6β,7α-dihydroxyroyleanone (4), and coleon U (5), isolated from Plectranthus grandidentatus Gürke, were evaluated for their in vitro antiproliferative activity against five human cancer cell lines MCF-7, NCI-H460, SF-268, TK-10, and UACC-62. Coleon U (5) exhibited the strongest effect among all the assayed compounds. The abietane 3 revealed also a strong inhibitory effect while diterpenes 2 and 4 inhibited only slightly the growth of all cancer cell lines.

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