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Synthesis 2002(12): 1740-1746
DOI: 10.1055/s-2002-33648
DOI: 10.1055/s-2002-33648
PAPER
© Georg Thieme Verlag Stuttgart · New York
A Versatile and Efficient Synthesis of 2-Alkyl and 2-Aryl-6-alkyl-2,3-dihydro-1H-pyridin-4-ones
Further Information
Received
4 April 2002
Publication Date:
05 September 2002 (online)
Publication History
Publication Date:
05 September 2002 (online)
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Abstract
A versatile and efficient method for the preparation of 2-alkyl and 2-aryl-6-alkyl-2,3-dihydro-1H-pyridin-4-ones is described. The sequence involved the condensation of β-amino acids and t-butyl ketoester to give enaminoesters whose intramolecular cyclisation followed by an hydrolysis step afforded the expected products.
Key words
β-amino ester - enaminoester - dihydropyridinone - ring closure - heterocycle
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