Shogaols from Zingiber officinale Protect IMR32 Human Neuroblastoma and Normal Human Umbilical Vein Endothelial Cells from β-Amyloid(25 - 35) Insult

Abstract

From the rhizome of Zingiber officinale L. (Zingiberaceae), four shogaols that protect IMR32 human neuroblastoma and normal human umbilical vein endothelial cells from β-amyloid(25 - 35) insult at EC₅₀ = 4.5 - 81 μM were isolated. The efficacy of cell protection from β-amyloid(25 - 35) insult by these shogaols was shown to improve as the length of the side chain increases.

References

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