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Synthesis 2002(6): 0720-0722
DOI: 10.1055/s-2002-25767
DOI: 10.1055/s-2002-25767
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York
A General Procedure for the Synthesis of 2-Substituted Pyrimidine-5-Carboxylic Esters
Further Information
Received
6 November 2001
Publication Date:
26 April 2002 (online)
Publication History
Publication Date:
26 April 2002 (online)
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Abstract
A method for the synthesis of 2-substituted pyrimidine-5-carboxylic esters is described. The sodium salt of 3,3-dimethoxy-2-methoxycarbonylpropen-1-ol (3) has been found to react with a variety of amidinium salts to afford the corresponding 2-substituted pyrimidine-5-carboxylic esters.
Keywords
heterocycles - pyrimidines - condensation - amidinium salt - esters
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