Taxuyunnanines S-V, New Taxoids from Taxus yunnanensis

Abstract

Four new 11(15→1)-abeotaxoids with an opened oxetane ring system, taxuyunnanines S, T, U and V (1 - 4) were isolated from the bark of Taxus yunnanensis. Taxuyunnanine S (1), is the most hydroxylated abeotaxoid discovered to date from Taxus species. The structures were determined by spectroscopic means including 1D and 2D NMR experiments.

Key words

Taxus yunnanensis - Taxaceae - bark - 11(15→1)-abeotaxoids - taxuyunnanines S, T, U and V - 1D and 2D NMR

References

• 1 Rao C, Liu X, Zhang P L, Chen W M, Fang Q C. Application of high-speed countercurrent chromatography for the isolation of natural products and preparative isolation of taxane diterpenoids and diterpene alkaloids.  Yaoxue Xuebao. 1991;  26 510-4
• 2 Xiang W, Zhang H J, Run D C, Sun H D. Contents of taxol and four other taxane diterpenoids in Taxus yunnanensis .  Zhiwu Ziyuan Yu Huanjing. 1997;  6 56-7
• 3 Zhang H J, Takeda Y, Minami Y, Yoshida K, Unemi N, Mu Q, Xiang W, Sun H D. Taxanes from the roots of Taxus yunnanensis .  Yunnan Zhiwu Yanjiu. 1993;  15 424-6
• 4 Zhang H J, Sun H D, Takeda Y. Four new taxanes from the roots of Taxus yunnanensis .  J. Nat.Prod.. 1995;  58 1153-9
• 5 Zhang H J, Mu Q, Xiang W, Yao P, Sun H D, Takeda Y. Intramolecular transesterified taxanes from Taxus yunnanensis. .  Phytochemistry. 1997;  44 911-5
• 6 Zhang H J, Takeda Y, Sun H D. Taxanes from Taxus yunnanensis .  Phytochemistry. 1995;  39 1147-51
• 7 Li S H, Zhang H J, Yao P, Sun H D. Two new taxoids from Taxus yunnanensis .  Chinese Chemistry Letters. 1998;  9 017-20
• 8 Li S H, Zhang H J, Yao P, Sun H D, Fong H HS. Rearranged taxanes from the bark of Taxus yunnanensis .  Journal of Natural Products. 2000;  63 1488-91
• 9 Li S H, Zhang H J, Yao P, Sun H D, Fong H HS. New taxane diterpenoids from the bark of Taxus yunnanensis . Phytochemistry 2001: in press
• 10 Zhang S, Lee C TL, Kashiwada Y, Chen K J. Yunantaxusin A, a new 11(15->1)-abeo-taxane from Taxus yunnanensis .  Journal of Natural Products. 1994;  57 1580-3