Clin Colon Rectal Surg 2001; 14(4): 309-316
DOI: 10.1055/s-2001-18509
Copyright © 2001 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Bowel Preparation for Colonoscopy

Oded Zmora, Steven D. Wexner
  • Dept. of Colorectal Surgery, Cleveland Clinic Florida, Weston, FL
Further Information

Publication History

Publication Date:
19 November 2001 (online)

ABSTRACT

The large bowel normally contains formed and solid stool, which hampers the performance of a safe and informative lower endoscopy. The aim of mechanical bowel preparation for colonoscopy is to rid the bowel of stool and permit adequate visualization of the entire colonic mucosa. For flexible sigmoidoscopy, which examines only the rectum and distal colon, cleansing of the rectosigmoid only is sufficient. Self-administered phosphate enemas provides adequate preparation in these cases, although several authors have advocated the addition of oral cathartic agents. However, for colonoscopy, a pancolonic mechanical bowel preparation is required. The newest methods of bowel cleansing with polyethylene glycol and sodium phosphate provide a high quality of preparation, with an acceptably low morbidity rate and a high degree of patient satisfaction, in a cost-effective manner. The current data suggest that mechanical bowel preparation with sodium phosphate is better tolerated by the patients and is the most commonly used preparation by colorectal surgeons for both colonoscopy and surgery. Both polyethylene glycol and sodium phosphate are associated with electrolyte and osmolarity imbalances, although greater changes have been found in patients who received sodium phosphate. Thus, in patients with a history of significant renal, heart, or liver disease, polyethylene glycol may be safer.

REFERENCES

  • 1 Manoucheri M, Nakamura D Y, Lukman R L. Bowel preparation for flexible sigmoidoscopy: which method yields the best results?.  J Fam Pract . 1999;  48 272-274
  • 2 Drew P J, Hughes M, Hodson R. The optimum bowel preparation for flexible sigmoidoscopy.  Eur J Surg Oncol . 1997;  23 315-316
  • 3 Osgard E, Jackson J L, Strong J. A randomized trial comparing three methods of bowel preparation for flexible sigmoidoscopy.  Am J Gastroenterol . 1998;  93 1126-1130
  • 4 Fincher R K, Osgard E M, Jackson J L. A comparison of bowel preparations for flexible sigmoidoscopy: oral magnesium citrate combined with oral bisacodyl, one hypertonic phosphate enema, or two hypertonic phosphate enemas.  Am J Gastroenterol . 1999;  94 2122-2127
  • 5 Preston K L, Peluso F E, Goldner F. Optimal bowel preparation for flexible sigmoidoscopy-are two enemas better than one?.  Gastrointest Endosc . 1994;  40 474-476
  • 6 Hewitt J, Reeve J, Rigby J. Whole-gut irrigation in preparation for large-bowel surgery.  Lancet . 1973;  18 337-340
  • 7 Panton O N, Atkinson K G, Crichton E P. Mechanical preparation of the large bowel for elective surgery. Comparison of whole-gut lavage with the conventional enema and purgative technique.  Am J Surg . 1985;  149 615-619
  • 8 Christensen P B, Kronborg O. Whole-gut irrigation versus enema in elective colorectal surgery: a prospective, randomized study.  Dis Colon Rectum . 1981;  24 592-595
  • 9 Crapp A R, Tillotson P, Powis S J. Preparation of the bowel by whole-gut irrigation.  Lancet . 1975;  20 1239-1240
  • 10 Downing R, Dorricott N J, Keighley M R. Whole gut irrigation: a survey of patient opinion.  Br J Surg . 1979;  66 201-202
  • 11 Donovan I A, Arabi Y, Keighley M R. Modification of the physiological disturbances produced by whole gut irrigation by preliminary mannitol administration.  Br J Surg . 1980;  67 138-139
  • 12 Minervini S, Alexander-Williams J, Donovan I A. Comparison of three methods of whole bowel irrigation.  Am J Surg . 1980;  140 400-402
  • 13 Zanoni C E, Bergamini C, Bertoncini M. Whole-gut lavage for surgery. A case of intraoperative colonic explosion after administration of mannitol.  Dis Colon Rectum . 1982;  25 580-581
  • 14 Keighley M R, Taylor E W, Hares M M. Influence of oral mannitol bowel preparation on colonic microflora and the risk of explosion during endoscopic diathermy.  Br J Surg . 1981;  68 554-556
  • 15 Goldman J, Reichelderfer M. Evaluation of rapid colonoscopy preparation using a new gut lavage solution.  Gastrointest Endosc . 1982;  28 9-11
  • 16 Ambrose N S, Johnson M, Burdon D W. A physiological appraisal of polyethylene glycol and a balanced electrolyte solution as bowel preparation.  Br J Surg . 1983;  70 428-430
  • 17 Bowden Jr A T, DiPiro J T, Michael K A. Polyethylene glycol electrolyte lavage solution (PEG-ELS). A rapid, safe mechanical bowel preparation for colorectal surgery.  Am Surg . 1987;  53 34-36
  • 18 Fleites R A, Marshall J B, Eckhauser M L. The efficacy of polyethylene glycol-electrolyte lavage solution versus traditional mechanical bowel preparation for elective colonic surgery: a randomized, prospective, blinded clinical trial.  Surgery . 1985;  98 708-717
  • 19 Paoluzi O A, Di Paolo C M, Ricci F. A randomized controlled trial of a new PEG-electrolyte solution compared with a standard preparation for colonoscopy.  Ital J Gastroenterol . 1993;  25 174-178
  • 20 Beck D E, Fazio V W. Current preoperative bowel cleansing methods. Results of a survey.  Dis Colon Rectum . 1990;  33 12-15
  • 21 Solla J A, Rothenberger D A. Preoperative bowel preparation. A survey of colon and rectal surgeons.  Dis Colon Rectum . 1990;  33 154-159
  • 22 Nichols R L, Smith J W, Garcia R Y. Current practices of preoperative bowel preparation among North American colorectal surgeons.  Clin Infect Dis . 1997;  24 609-619
  • 23 Grundel K, Schwenk W, Bohm B. Improvements in mechanical bowel preparation for elective colorectal surgery.  Dis Colon Rectum . 1997;  40 1348-1352
  • 24 Oliveira L, Wexner S D, Daniel N. Mechanical bowel preparation for elective colorectal surgery. A prospective, randomized, surgeon-blinded trial comparing sodium phosphate and polyethylene glycol-based oral lavage solutions.  Dis Colon Rectum . 1997;  40 585-591
  • 25 Rosch T, Classen M. Fractional cleansing of the large bowel with ``Golytely'' for colonoscopic preparation: a controlled trial.  Endoscopy . 1987;  19 198-200
  • 26 Brady C E, DiPalma J A, Pierson W P. Golytely lavage-is metoclopramide necessary?.  Am J Gastroenterol . 1985;  80 180-184
  • 27 Cohen S M, Wexner S D, Binderow S R. Prospective, randomized, endoscopic-blinded trial comparing precolonoscopy bowel cleansing methods.  Dis Colon Rectum . 1994;  37 689-696
  • 28 Frommer D. Cleansing ability and tolerance of three bowel preparations for colonoscopy.  Dis Colon Rectum . 1997;  40 100-104
  • 29 Chan A, Depew W, Vanner S. Use of oral sodium phosphate colonic lavage solution by Canadian colonoscopists: pitfalls and complications.  Can J Gastroenterol . 1997;  11 334-338
  • 30 Henderson J M, Barnett J L, Turgeon D K. Single-day, divided-dose oral sodium phosphate laxative versus intestinal lavage as preparation for colonoscopy: efficacy and patient tolerance.  Gastrointest Endosc . 1995;  42 238-243
  • 31 Marshall J B, Pineda J J, Barthel J S. Prospective, randomized trial comparing sodium phosphate solution with polyethylene glycol-electrolyte lavage for colonoscopy preparation.  Gastrointest Endosc . 1993;  39 631-634
  • 32 Hsu C W, Imperiale T F. Meta-analysis and cost comparison of polyethylene glycol lavage versus sodium phosphate for colonoscopy preparation.  Gastrointest Endosc . 1998;  48 276-282
  • 33 Yoshioka K, Connolly A B, Ogunbiyi O A. Randomized trial of oral sodium phosphate compared with oral sodium picosulphate (Picolax) for elective colorectal surgery and colonoscopy.  Dig Surg . 2000;  17 66-70
  • 34 Aronchick C A, Lipshutz W H, Wright S H. A novel tableted purgative for colonoscopic preparation: efficacy and safety comparisons with Colyte and Fleet Phospho-Soda.  Gastrointest Endosc . 2000;  52 346-352
  • 35 Linden T B, Waye J D. Sodium phosphate preparation for colonoscopy: onset and duration of bowel activity.  Gastrointest Endosc . 1999;  50 811-813
  • 36 Church J M. Effectiveness of polyethylene glycol antegrade gut lavage bowel preparation for colonoscopy-timing is the key! Dis Colon Rectum .  1998;  41 1223-1225
  • 37 DiPalma J A, Brady III E C, Stewart D L. Comparison of colon cleansing methods in preparation for colonoscopy.  Gastroenterology . 1984;  86 856-860
  • 38 Habr-Gama A, Bringel R W, Nahas S C. Bowel preparation for colonoscopy: comparison of mannitol and sodium phosphate. Results of a prospective randomized study.  Rev Hosp Clin Fac Med Sao Paulo . 1999;  54 187-192
  • 39 Clarkston W K, Tsen T N, Dies D F. Oral sodium phosphate versus sulfate-free polyethylene glycol electrolyte lavage solution in outpatient preparation for colonoscopy: a prospective comparison.  Gastrointest Endosc . 1996;  43 42-48
  • 40 Lieberman D A, Ghormley J, Flora K. Effect of oral sodium phosphate colon preparation on serum electrolytes in patients with normal serum creatinine.  Gastrointest Endosc . 1996;  43 467-469
  • 41 Gremse D A, Sacks A I, Raines S. Comparison of oral sodium phosphate to polyethylene glycol-based solution for bowel preparation for colonoscopy in children.  J Pediatr Gastroenterol Nutr . 1996;  23 586-590
  • 42 Campisi P, Badhwar V, Morin S. Postoperative hypocalcemic tetany caused by Fleet Phospho-Soda preparation in a patient taking alendronate sodium: report of a case.  Dis Colon Rectum . 1999;  42 1499-1501
  • 43 Turnage R H, Guice K S, Gannon P. The effect of polyethylene glycol gavage on plasma volume.  J Surg Res . 1994;  57 284-288
  • 44 Granberry M C, White L M, Gardner S F. Exacerbation of congestive heart failure after administration of polyethylene glycol-electrolyte lavage solution.  Ann Pharmacother . 1995;  29 1232-1235
  • 45 Zwas F R, Cirillo N W, El-Serag H B. Colonic mucosal abnormalities associated with oral sodium phosphate solution.  Gastrointest Endosc . 1996;  43 463-466
  • 46 Coskun A, Uzunkoy A, Duzgun S A. Experimental sodium phosphate and polyethylene glycol induce colonic tissue damage and oxidative stress.  Br J Surg . 2001;  88 85-89
  • 47 Keighley M R. A clinical and physiological evaluation of bowel preparation for elective colorectal surgery.  World J Surg . 1982;  6 464-670
  • 48 Beck D E, DiPalma J A. A new oral lavage solution vs cathartics and enema method for preoperative colonic cleansing.  Arch Surg . 1991;  126 552-555
  • 49 Beck D E, Fazio V W, Jagelman D G. Comparison of oral lavage methods for preoperative colonic cleansing.  Dis Colon Rectum . 1986;  29 699-703
  • 50 Beck D E, Harford F J, DiPalma J A. Comparison of cleansing methods in preparation for colonic surgery.  Dis Colon Rectum . 1985;  28 491-495
  • 51 Lee J, McCallion K, Acheson A G. A prospective randomised study comparing polyethylene glycol and sodium phosphate bowel cleansing solutions for colonoscopy.  Ulster Med J . 1999;  68 68-72
  • 52 Vanner S J, MacDonald P H, Paterson W G. A randomized prospective trial comparing oral sodium phosphate with standard polyethylene glycol-based lavage solution (Golytely) in the preparation of patients for colonoscopy.  Am J Gastroenterol . 1990;  85 422-427
  • 53 Kolts B E, Lyles W E, Achem S R. comparison of the effectiveness and patient tolerance of oral sodium phosphate, castor oil, and standard electrolyte lavage for colonoscopy or sigmoidoscopy preparation.  Am J Gastroenterol . 1993;  88 1218-1223
  • 54 Marshall J B, Pineda J J, Barthel J S. Prospective, randomized trial comparing sodium phosphate solution with polyethylene glycol-electrolyte lavage for colonoscopy preparation.  Gastrointest Endosc . 1993;  39 631-634
  • 55 Henderson J M, Barnett J L, Turgeon D K. Single-day, divided-dose oral sodium phosphate laxative versus intestinal lavage as preparation for colonoscopy: efficacy and patient tolerance.  Gastrointest Endosc . 1995;  42 238-243
  • 56 Golub R W, Kerner B A, Wise Jr E W. Colonoscopic bowel preparations-which one?.  <~>A blinded, prospective, randomized trial. Dis Colon Rectum . 1995;  38 594-599
  • 57 Chia Y W, Cheng L C, Goh P M. Role of oral sodium phosphate and its effectiveness in large bowel preparation for out-patient colonoscopy.  J R Coll Surg Edinb . 1995;  40 374-376
  • 58 Afridi S A, Barthel J S, King P D. Prospective, randomized trial comparing a new sodium phosphate-bisacodyl regimen with conventional PEG-ES lavage for outpatient colonoscopy preparation.  Gastrointest Endosc . 1995;  41 485-489
  • 59 Thomson A, Naidoo P, Crotty B. Bowel preparation for colonoscopy: a randomized prospective trail comparing sodium phosphate and polyethylene glycol in a predominantly elderly population.  J Gastroenterol Hepatol . 1996;  11 103-107
  • 60 Unal S, Dogan U B, Ozturk Z. A randomized prospective trial comparing 45 and 90-ml oral sodium phosphate with X-Prep in the preparation of patients for colonoscopy.  Acta Gastroenterol Belg . 1998;  61 281-284
  • 61 Arezzo A. Prospective randomized trial comparing bowel cleaning preparations for colonoscopy.  Surg Laparosc Endosc Percutan Tech . 2000;  10 215-217
  • 62 Bini E J, Unger J S, Rieber J M. Prospective, randomized, single-blind comparison of two preparations for screening flexible sigmoidoscopy.  Gastrointest Endosc . 2000;  52 218-522
  • 63 Young C J, Simpson R R, King D W. Oral sodium phosphate solution is a superior colonoscopy preparation to polyethylene glycol with bisacodyl.  Dis Colon Rectum. 2000;  43 1568-1571