Synthesis of Polyhydroxylated Derivatives of Phenyl Vinyl Sulfone as Structural Analogs of Chalcones

Abstract

A series of polyhydroxylated phenyl vinyl sulfones was prepared by phase transfer condensation of suitable phenyl methyl sulfones with substituted benzaldehydes. The compounds were prepared as structural analogs of biologically active chalcones. One of the compounds was cyclized to a derivative of 2,3-dihydro-2-phenyl-1,4-benzoxathiin-4,4-dioxide, a heterocyclic system closely resembling flavanones.

Key words

phenyl vinyl sulfones - 1,4-benzoxathiin-4,4-dioxide - chalcones - flavanones

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