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Dtsch Med Wochenschr 2001; 126(Suppl. Gastroenterol. 1): S1-S7
DOI: 10.1055/s-2001-14497
Supplement Gastroenterologie (1)
© Georg Thieme Verlag Stuttgart · New York

Diagnostik bei der Ulkuskrankheit:
Was ist nötig, was ist überflüssig?

Diagnosis of ulcerative disease: what is essential and what is not necessary?J. Mössner
  • Medizinische Klinik und Poliklinik II der Universität Leipzig
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Publication History

Publication Date:
11 September 2002 (online)

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Überlegungen zur nötigen und überflüssigen Diagnostik des Ulkusleidens setzen eine Kenntnis der unterschiedlichen Pathomechanismen der Erkrankung, der Klinik, der Differentialdiagnose und der potenziellen Folgekomplikationen voraus.

Literatur

  • 1 Barenys M, Abad A, Pons J M, Moreno V, Rota R, Granados A, Admetlla M, Pique J M. Scoring system has better discriminative value than Helicobacter pylori testing in patients with dyspepsia in a setting with high prevalence of infection.  Eur J Gastroenterol Hepatol. 2000;  12 1275-1282
    Google Scholar
  • 2 Bjorkman D J. Current status of nonsteroidal anti-inflammatory drug (NSAID) use in the United States: risk factors and frequency of complications.  Am J Med 1999. 107 3S-8S; discussion 8S-10S
    Google Scholar
  • 3 Blum A L, Talley N J, O’Morain C, van Zanten S V, Labenz J, Stolte M, Louw J A, Stubberod A, Theodors A, Sundin M, Bolling-Sternevald E, Junghard O. Lack of effect of treating Helicobacter pylori infection in patients with nonulcer dyspepsia. Omeprazole plus Clarithromycin and Amoxicillin. Effect One Year after Treatment (OCAY) Study Group.  N Engl J Med. 1998;  339 1875-1881
    Google Scholar
  • 4 Chey W D. Accurate diagnosis of Helicobacter pylori. 14C-urea breath test.  Gastroenterol Clin North Am. 2000;  29 895-902
    Google Scholar
  • 5 Cohen H. Peptic ulcer and Helicobacter pylori.  Gastroenterol Clin North Am. 2000;  29 775-789
    Google Scholar
  • 6 Cook D J, Fuller H D, Guyatt G H, Marshall J C, Leasa D, Hall R, Winton T L, Rutledge F, Todd T JR, Roy P, Lacroix J, Griffith L, Willan A, for t he Canadian Critical Care Trials Group. Risk factors for gastrointestinal bleeding in crticially ill patients.  N Engl J Med. 1994;  330 377-381
    Google Scholar
  • 7 Dixon M F, Genta R M, Yardley J H, Correa P. Histological classification of gastritis and Helicobacter pylori infection: an agreement at last? The International Workshop on the Histopathology of Gastritis.  Helicobacter. 1997;  2 S17-24 ((Suppl 1))
    Google Scholar
  • 8 Fendrick A M. The role of economic evaluation in the diagnosis and treatment of Helicobacter pylori infection.  Gastroenterol Clin North Am. 2000;  29 837-851
    Google Scholar
  • 9 Fischbach W, Dragosics B, Kolve-Goebeler M E, Ohmann C, Greiner A, Yang Q, Böhm S, Verreet P, Horstmann O, Busch M, Duhmke E, Müller-Hermelink H K, Wilms K. The German-Austrian Gastrointestinal Lymphoma Study Group . Primary gastric B-cell lymphoma: results of a prospective multicenter study.  Gastroenterology. 2000;  119 1191-1202
    Google Scholar
  • 10 Gisbert J P, Benito L M, Lara S, Vazquez A, Jimenez I, Pajares J M. 13C-urea breath test for the diagnosis of Helicobacter pylori infection: are basal samples necessary?.  Eur J Gastroenterol Hepatol. 2000;  12 1201-1205
    Google Scholar
  • 11 Graham D Y, Lew G M, Klein P D, Evans D G, Evans D J, Saeed Z A. et al . Effect of treatment of Helicobacter pylori infection on the long-term recurrence of gastric and duodenal ulcer.  Ann Intern Med. 1992;  116 705-708
    Google Scholar
  • 12 Graham D Y, Go M F. Helicobacter pylori: current status.  Gastroenterology. 1993;  105 279-282
    Google Scholar
  • 13 Graham D Y, Klein P D. Accurate diagnosis of Helicobacter pylori. 13C-urea breath test.  Gastroenterol Clin North Am. 2000;  29 885-893
    Google Scholar
  • 14 Halm U, Halm F, Thein D, Mohr F W, Mössner J. Helicobacter pylori infection: a risk factor for upper gastrointestinal bleeding after cardiac surgery?.  Crit Care Med. 2000;  28 110-113
    Google Scholar
  • 15 Hawkey C J, Karrasch J A, Szczepanski L, Walker D G, Barkun A, Swannell A J, Yeomans N D. Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs. Omeprazole versus Misoprostol for NSAID-induced Ulcer Management (OMNIUM) Study Group.  N Engl J Med. 1998;  338 727-734
    Google Scholar
  • 16 Ho G Y, Windsor H M. Accurate diagnosis of Helicobacter pylori. Polymerase chain reaction tests.  Gastroenterol Clin North Am. 2000;  29 903-915
    Google Scholar
  • 17 Ho B, Marshall B J. Accurate diagnosis of Helicobacter pylori. Serologic testing.  Gastroenterol Clin North Am. 2000;  29 853-62
    Google Scholar
  • 18 Marshall B J, Warren J R. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration.  Lancet. 1984;  1 1311-1315
    Google Scholar
  • 19 McColl K, Murray L, El-Omar E, Dickson A, El-Nujumi A, Wirz A, Kelman A, Penny C, Knill-Jones R, Hilditch T. Symptomatic benefit from eradicating Helicobacter pylori infection in patients with nonulcer dyspepsia.  N Engl J Med. 1998;  339 1869-1874
    Google Scholar
  • 20 Midolo P, Marshall B J. Accurate diagnosis of Helicobacter pylori. Urease tests.  Gastroenterol Clin North Am. 2000;  29 871-878
    Google Scholar
  • 21 Misiewicz J J, Tytgat G NJ, Goodwin C S. et al .The Sydney System: a new classification of gastritis. Melbourne, Australia: Blackwell Scientific Publications In: Proceedings of the Working Party Report for the Sydney World Congress of Gastroenterology, Sydney, Australia, August 26-31, 1990 1990: 1-10
    Google Scholar
  • 22 Monteiro L, de Mascarel A, Sarrasqueta A M, Bergey B, Barberis C, Talby P, Roux D, Shouler L, Goldfain D, Lamouliatte H, Megraud F. Diagnosis of Helicobacter pylori infection: noninvasive methods compared to invasive methods and evaluation of two new tests.  Am J Gastroenterol. 2001;  96 353-358
    Google Scholar
  • 23 Norton J A, Fraker D L, Alexander H R, Venzon D J, Doppman J L, Serrano J, Goebel S U, Peghini P L, Roy P K, Gibril F, Jensen R T. Surgery to cure the Zollinger-Ellison syndrome.  N Engl J Med. 1999;  341 635-644
    Google Scholar
  • 24 Parsonnet J. The incidence of Helicobacter pylori infection.  Aliment Pharmacol Ther. 1995;  9 45-51 (Suppl 2)
    Google Scholar
  • 25 Perez-Perez G I. Accurate diagnosis of Helicobacter pylori. Culture, including transport.  Gastroenterol Clin North Am. 2000;  29 879-884
    Google Scholar
  • 26 Proye C, Malvaux P, Pattou F, Filoche B, Godchaux J M, Maunoury V, Palazzo L, Huglo D, Lefebvre J, Paris J C. Noninvasive imaging of insulinomas and gastrinomas with endoscopic ulttrasonography and somatostatin receptor scintigraphy.  Surgery. 1998;  124 1134-1143; discussion 1143-1144
    Google Scholar
  • 27 Rosenstock S J, Jorgensen T. Prevalence and incidence of peptic ulcer disease in a Danish County-a prospective cohort study.  Gut. 1995;  36 819-824
    Google Scholar
  • 28 Russmann H, Kempf V A, Koletzko S, Heesemann J, Autenrieth I B. Comparison of fluorescent in situ hybridization and conventional culturing for detection of Helicobacter pylori in gastric biopsy specimens.  J Clin Microbiol. 2001;  39 304-308
    Google Scholar
  • 29 Savarino V, Tracci D, Dulbecco P, Mele M R, Zentilin P, Mansi C, Vigneri S. Negative effect of ranitidine on the results of urea breath test for the diagnosis of Helicobacter pylori.  Am J Gastroenterol. 2001;  96 348-352
    Google Scholar
  • 30 Schenk B E, Kuipers E J, Nelis G F, Bloemena E, Thijs J C, Snel P, Luckers A E, Klinkenberg-Knol E C, Festen H P, Viergever P P, Lindeman J, Meuwissen S G. Effect of Helicobacter pylori eradication on chronic gastritis during omeprazole therapy.  Gut. 2000;  46 615-621
    Google Scholar
  • 31 Schilling D, Jakobs R, Peitz U, Sulliga M, Stolte M, Riemann J F, Labenz J. Diagnostic accuracy of (13)C-Urea Breath Test in the diagnosis of Helicobacter pylori infection in patients with partial gastric resection due to peptic ulcer disease. a prospective multicenter study.  Digestion. 2001;  63 8-13
    Google Scholar
  • 32 Silverstein F E, Graham D Y, Senior J R, Davies H W, Struthers B J, Bittman R M, Geis G S. Misoprostol reduces serious gastrointestinal complications in patients with rheumatoid arthritis receiving nonsteroidal anti-inflammatory drugs. A randomized, double-blind, placebo-controlled trial.  Ann Intern Med. 1995;  123 241-249
    Google Scholar
  • 33 Soll A H. Pathogenesis of peptic ulcer and implications for therapy.  N Engl J Med. 1991;  324 1043-1048
    Google Scholar
  • 34 Sung J, Russell R I, Yeomans N, Chan F K, Chen S, Fock K, Goh K L, Kullavanijaya P, Kimura K, Lau C, Louw J, Sollano J, Triadiafalopulos G, Xiao S, Brooks P. Non-steroidal anti-inflammatory drug toxicity in the upper gastrointestinal tract.  J Gastroenterol Hepatol. 2000;  15 G58-68 (Suppl))
    Google Scholar
  • 35 Talley N J, Vakil N, Ballard E D, Fennerty M B. Absence of benefit of eradicating Helicobacter pylori in patients with nonulcer dyspepsia.  N Engl J Med. 1999;  341 1106-1111
    Google Scholar
  • 36 Vaira D, Menegatti M, Ricci C, Gatta L, Berardi S, Miglioli M. Accurate diagnosis of Helicobacter pylori. Stool tests.  Gastroenterol Clin North Am. 2000;  29 917-923
    Google Scholar
  • 37 Valori R M, Cockel R. Omeprazole for duodenal ulceration in Crohn’s disease.  BMJ. 1990;  300 438-439
    Google Scholar
  • 38 Wilcox C M, Shalek K A, Cotsonis G. Striking prevalence of over-the-counter nonsteroidal anti-inflammatory drug use in patients with upper gastrointestinal hemorrhage.  Arch Intern Med. 1994;  154 42-46
    Google Scholar
  • 39 Wilcox C M, Alexander L N, Cotsonis G A, Clark W S. Nonsteroidal antiinflammatory drugs are associated with both upper and lower gastrointestinal bleeding.  Dig Dis Sci. 1997;  42 990-997
    Google Scholar
  • 40 Yeomans N D, Garas G, Hawkey C J. The nonsteroidal anti-inflammatory drugs controversy.  Gastroenterol Clin North Am. 2000;  29 791-805
    Google Scholar
  • 41 el-Zimaity H M. Accurate diagnosis of Helicobacter pylori with biopsy.  Gastroenterol Clin North Am. 2000;  29 863-869
    Google Scholar

Korrespondenz

Prof. Dr. med. Joachim Mössner

Medizinische Klinik und Poliklinik II Zentrum für Innere Medizin Universität Leipzig

Philipp-Rosenthal-Straße 27

04103 Leipzig

Phone: 0341/9712201

Fax: 0341/9712209

Email: moej@medizin.uni-leipzig.de