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DOI: 10.1055/s-2001-11020
© Johann Ambrosius Barth
Approaches to gene therapy with sodium/iodide symporter
Publication History
Publication Date:
31 December 2001 (online)
![](https://www.thieme-connect.de/media/eced/200101/lookinside/thumbnails/10.1055-s-2001-11020-1.jpg)
Summary:
Since cloning and characterization of the sodium iodide symporter (NIS) gene, several investigators explored the possibility of a novel cytoreductive gene therapy strategy based on NIS gene transfer into non-thyroidal tumor cells followed by radioiodine therapy. NIS gene transfer has been shown to be capable of inducing radioiodine accumulation in vitro and in vivo in several non-thyroidal cancer cell lines. Following PSA promoter-mediated NIS gene delivery we were able to demonstrate prostate-specific iodide accumulation in prostate cancer cells that was high enough to elicit a therapeutic response of 131-I in vitro and in vivo. This study clearly demonstrates the potential of NIS as a novel therapeutic gene for non-thyroidal cancers, in particular prostate cancer.
Key words:
Sodium/iodide symporter (NIS) - gene therapy - prostate cancer
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Christine SpitzwegM.D.
Mayo Clinic
Endocrine Research Unit
Guggenheim 625 200 First Street SW
Rochester, MN 55905
USA
Phone: 507-284-2324
Fax: 507-284-4521
Email: spitzweg.christine@mayo.edu