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Planta Med 2001; 67(1): 74-76
DOI: 10.1055/s-2001-10874
Letters
Georg Thieme Verlag Stuttgart · New York

Monoamine Oxidase Inhibitors from Rhizoma of Coptis chinensis

Ling Dong Kong1,3 , Christopher H.K. Cheng2 , Ren Xiang Tan1,*
  • 1 Institute of Functional Biomolecule, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, People's Republic of China
  • 2 Department of Biochemistry, The Chinese University of Hong Kong, Shatin, N. T., Hong Kong
  • 3 National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, People's Republic of China
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Publication History

Publication Date:
31 December 2001 (online)

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Abstract

Three protoberberine alkaloids jatrorrhizine, berberine and palmatine were isolated from the monoamine oxidase (MAO) inhibitory fraction of the methanol extract of Coptis chinensis rhizoma. Jatrorrhizine was shown to inhibit non-competitively both MAO-A and -B from rat brain mitochondria with the IC50 values of 4 and 62 μM, respectively. Berberine only competitively inhibited MAO-A with an IC50 values of 126 μM whereas palmatine exhibited, up to 200 μM, no inhibition on any type of the enzyme. The structure-activity relationship was briefly discussed.

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Prof. Dr. R. X. Tan

Institute of Functional Biomolecule

School of Life Sciences

Nanjing University

Nanjing 210093

P. R. China

Email: rxtan@netra.nju.edu.cn

Phone: & +86 25 359 3201