Semin Liver Dis 2000; Volume 20(Number 03): 307-322
DOI: 10.1055/s-2000-9386
Copyright © 2000 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Short-Term Regulation of Canalicular Transport

DIETER. HÄUSSINGER, MARCUS. SCHMITT, OLIVER. WEIERGRÄBER, RALF. KUBITZ
  • From the Medizinische Universitätsklinik, Heinrich Heine Universität, Düsseldorf, Germany
Further Information

Publication History

Publication Date:
31 December 2000 (online)

ABSTRACT

On a short term basis, canalicular secretion is under control of the hepatocellular hydration state, substrates, cytokines, toxins, and hormones. Regulation occurs at the level of substrate availability, covalent modification of transporters, and their regulated exocytic insertion into or endocytic retrieval from the membrane. A variety of signal transduction pathways involving the activation of mitogen-activated protein kinases, protein kinases A and C, participates in these processes. However, much has still to be learned about the crosstalk of different signaling systems and their molecular targets that determine the outcome for canalicular secretion.

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