Subscribe to RSS
DOI: 10.1055/s-2000-8572
Anti-Inflammatory and Analgesic Activities of the Latex Containing Triterpenes from Himatanthus sucuuba
Publication History
Publication Date:
31 December 2000 (online)
![](https://www.thieme-connect.de/media/plantamedica/200003/lookinside/thumbnails/10.1055-s-2000-8572-1.jpg)
Abstract
Some triterpenes and iridoids were previously isolated from the stem bark of Himatanthus sucuuba. The latex from Himatanthus sucuuba is used in popular amazonian medicine as an anti-inflammatory remedy. Fractions of the latex were pharmacologically evaluated with a view to verify this popular use in the carrageenan-induced rat paw edema and in the acetic acid-induced mouse constriction tests. The hexane fraction inhibited the edema formation by 35.9 % at a dose of 200 mg/kg (p.o.) but no activity was observed at 100 mg/kg (p.o.). The triterpenes present in the hexane fraction were identified as lupeol acetate, α-amyrin and lupeol cinnamates. The fraction containing only cinnamates inhibited the edema and the abdominal constrictions by 50 - 40 % and 57.9 %, respectively, at 100 mg/kg (p.o.). Among all the fractions studied, the fraction containing only cinnamates showed the greatest anti-inflammatory activity which suggests that these compounds were responsible for the previously described activity of the crude extract.
References
-
1 Van den Berg M E..
Plantas Medicinais na Amazônia: Contribuição ao seu Conhecimento Sistema¿tico, . CNPq/PRU/MPEG, Belém, Brasil; 1982: 212 - 2 Perdue G P,, Blomster R N.. South American Plants III: Isolation of fulvoplumierin from Himatanthus sucuuba (M. Arg.) Woodson (Apocynaceae). J. Pharm. Sci.. 1978;; 67 1322-3
- 3 Endo Y,, Hayashi H,, Sato T,, Maruno M,, Ohta T,, Nozoe S.. Confluetic acid and 2′-O-methylperlatolic acid, monoamine oxidase B inhibitors in a Brazilian plant, Himatanthus sucuuba. . Chem. Pharm. Bull.. 1994;; 42 1198-201
- 4 Silva J RA,, Rezende C M,, Pinto A C,, Pinheiro M LB,, Cordeiro M C,, Tamborini E,, Young C M,, Bolzani V S.. Ésteres triterpênicos de Himatanthus sucuuba (Spruce) Woodson. Quim. Nova. 1998;; 21 702-4
- 5 Vinegar R,, Truaux J F,, Selph J L.. Quantitative studies of pathway to acute carrageenan inflammation. Fed. Proc.. 1976;; 35 2447-56
- 6 Recio M C,, Giner R M,, Manez S,, Rios J L.. Structural requirements for the anti-inflammatory activity of natural triterpenoids. Planta Medica. 1995;; 61 182-5
- 7 Singh S,, Bani S,, Singh G B,, Gupta B D,, Banerjee S K,, Singh B.. Anti-inflammatory activity of lupeol. Fitoterapia. 1997;; LXVIII(1) 9-16
- 8 Recio M C,, Giner R M,, Manez S,, Gueho J,, Julien H R,, Hostettmann K,, Rios J L.. Investigations on the steroidal anti-inflammatory activity of triterpenoids from Diospyros leucomelas. . Planta Medica. 1995;; 61 9-12
- 9 Singh G B,, Singh S,, Bani S,, Gupta B D,, Banerjee S K.. Anti-inflammatory activity of oleanolic acid in rats and mice. J. Pharm. Pharmacol.. 1992;; 44 456-8
- 10 Gupta M B,, Bhalla T N,, Tangri K K,, Bhargava K P.. Biochemical study of the anti-inflammatory activity of α- and β-amyrin acetate. Biochem. Pharmacol.. 1971;; 20 401-5
- 11 Gupta M B,, Bhalla T N,, Gupta G P,, Mitra C R,, Bhargava K P.. Anti-inflammatory activity of natural products (1) triterpenoids. Eur. J. Pharmacol.. 1969;; 6 67-70
- 12 Ribeiro I G,, Silva K CM,, Parrini S C,, Miranda A LP,, Fraga C AM,, Barreiro E J.. Synthesis and antinociceptive properties of new structurally planned imidazo[1,2-a]pyridine 3-acylhydrazone derivatives. Eur. J. Med. Chem.. 1998;; 33 225-35
Dr. Angelo da
Cunha
Pinto
Departamento de Química Orgânica Instituto de Química
UFRJ, 21945-970
Rio de Janeiro, RJ
Brazil
Email: angelo@iq.ufrj.br
Phone: +55.21.2904746