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DOI: 10.1055/s-2000-7488
Georg Thieme Verlag Stuttgart · New York
Painless Fractures and Thermoregulation Disturbances in Sensory-Autonomic Neuropathy: Electrophysiological Abnormalities and Sural Nerve Biopsy
Publication History
Publication Date:
31 December 2000 (online)
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We describe the case of a young girl suffering from thermoregulation disturbances, painless fractures and arthropathy since early childhood. The patient was diagnosed as having a hereditary sensory autonomic neuropathy. Although needle EMG, conventional nerve conduction studies and somatosensory evoked potentials gave normal results, sympathetic skin responses (SSRs) were absent. Sural nerve biopsy showed a substantial reduction in the number of small myelinated and unmyelinated fibers.
We emphasize the importance of SSR testing in revealing a condition which is otherwise difficult to identify by electrophysiological techniques. The combined evidence of functional and morphological findings is strongly suggestive of selective peripheral nerve involvement.
Key words
Painless fractures - Autonomic neuropathy - Sympathetic skin response - Sural nerve biopsy
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Dr. A. Polo
Dipartimento di Scienze Neurologiche e della Visione Sezione di Neurologia Policlinico Borgo Roma
37134 Verona
Italy