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Am J Perinatol 2000; 17(7): 377-384
DOI: 10.1055/s-2000-13446
Copyright © 2000 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

FUNCTIONAL RESIDUAL CAPACITY AND STATIC COMPLIANCE DURING THE FIRST YEAR IN PRETERM INFANTS TREATED WITH SURFACTANT

J. P. de Winter1 , I. T. Merth1 , R. Brand2 , Ph. H. Quanjer3
  • 1Department of Pediatrics, Leiden University Medical Centre, The Netherlands
  • 2Department of Medical Statistics, Leiden University Medical Centre, The Netherlands
  • 3Department of Physiology, Leiden University Medical Centre, The Netherlands. Current affiliations: J.P. de Winter, University Hospital Utrecht/Wilhelmina Children's Hospital University of Utrecht; and I.T. Merth, Hospital Twenteborg, Almelo
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Publication Date:
31 December 2000 (online)

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ABSTRACT

Individual lung development during the first year of life was studied in surfactant treated preterm infants with respiratory distress syndrome (RDS) and healthy controls, as well as in a group who subsequently developed chronic lung disease of the newborn (CLDN). Lung development was assessed from functional residual capacity (FRC) and compliance of the respiratory system (Crs). Twenty-one infants with RDS after preterm birth received surfactant treatment. Six of them developed CLDN. Eighteen preterm infants without RDS served as a control group. Lung function measurements were performed at term age and 4, 8, and 12 months afterwards. FRC was obtained by means of the closed-system helium dilution technique whereas static Crs was obtained by means of the weighted spirometer technique. At term age, FRC was lower in the CLDN group compared with uncomplicated RDS and controls (p < 0.05). No significant differences between groups were found in the development of FRC during the first year of life (p = 0.4). No differences were found in Crs during the first year of life in surfactant treated infants who recovered from uncomplicated RDS and the control group. However, lower values were found in the CLDN group (p < 0.05). We conclude that surfactant treated infants without CLDN have similar lung development during the first year of life as control preterm infants.

KEYWORD

Prematurity - surfactant - lung function testing

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