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Semin Neurol 2000; 20(4): 463-470
DOI: 10.1055/s-2000-13179
Copyright © 2000 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

Neglect and Related Disorders

Kenneth M. Heilman, Edward Valenstein, Robert T. Watson
  • Department of Neurology, University of Florida College of Medicine, Center for Neuropsychological Studies, and Malcom Randall Department of Veterans Affairs Medical Center, Gainesville, Florida
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Publication History

Publication Date:
03 March 2004 (online)

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ABSTRACT

Neglect is a failure to report, respond, or orient to contralateral stimuli that is not caused by an elemental sensorimotor deficit. Subtypes of neglect are distinguished by input (attentional) or output (intentional) demands, the distribution (personal, spatial, and representational), and the means of eliciting the signs (unilateral or bilateral stimuli). In this article we discuss how to assess patients for neglect, the pathophysiology of neglect, and the treatment of neglect.

KEYWORD

Neglect - unilateral neglect - hemispatial neglect - inattention

REFERENCES

  • 1 Heilman K M, Valenstein E, Watson R T. Neglect and related disorders. In: Heilman KM, Valenstein E, eds. Clinical Neuropsychology New York: Oxford University Press; 1993
    Google Scholar
  • 2 Triggs W J, Gold M, Gerstle G, Adair J, Heilman K M. Motor neglect associated with a discreet parietal lesion.  Neurology . 1994;  44 1164-1166
    PubMedGoogle Scholar
  • 3 Meador K, Watson R T, Bowers D, Heilman K M. Hypometria with hemispatial and limb motor neglect.  Brain . 1986;  109 293-305
    PubMedGoogle Scholar
  • 4 Heilman K M, Watson R T. Intentional motor disorders. In: Levin HS, Eisenbery HM, Benton A, eds. Frontal Lobe Function New York: Oxford University Press 1989: 199-213
    Google Scholar
  • 5 Valenstein E, Heilman K M. Unilateral hypokinesia and motor extinction.  Neurology . 1981;  31 445-448
    PubMedGoogle Scholar
  • 6 Mennemeier M, Chatterjee A, Heilman K M. Influences of body and environmentally centered reference frames of neglect in horizontal, vertical and radical dimension.  Brain . 1994;  117 1013-1021
    PubMedGoogle Scholar
  • 7 Halligan P W, Marshall J C. How long is a piece of string?.  <~>A study of line bisection in a case of visual neglect. Cortex . 1988;  24 321-328
    PubMedGoogle Scholar
  • 8 Heilman K M, Valenstein E. Mechanisms underlying hemispatial neglect.  Ann Neurol . 1979;  5 166-170
    CrossrefPubMedGoogle Scholar
  • 9 Coslett H B, Bowers D, Fitzpatrick E, Haws B, Heilman K M. Directional hypokinesia and hemispatial inattention in neglect.  Brain . 1990;  113 475-486
    CrossrefPubMedGoogle Scholar
  • 10 Bisiach E, Geminiani G, Berti A, Rusconi M L. Preceptual and premotor factors of unilateral neglect.  Neurology . 1990;  40 1278-1281
    PubMedGoogle Scholar
  • 11 Gold M, Shuren J, Heilman K M. Proximal intentional neglect: a case study.  J Neurol Neurosurg Psychiatry . 1994;  57 1395-1400
    PubMedGoogle Scholar
  • 12 Ladavas E. Is the hemispatial deficit produced by right parietal damage associated with retinal or gravitational coordinates?.  Brain . 1987;  110 167-180
    PubMedGoogle Scholar
  • 13 Bisiach E, Luzzatti C. Unilateral neglect of representational space.  Cortex . 1978;  14 29-33
    PubMedGoogle Scholar
  • 14 Coslett H B. Neglect in vision and visual imagery: a double dissociation.  Brain . 1997;  120 1163-1171
    CrossrefPubMedGoogle Scholar
  • 15 Hernandez-Peon R, Scherrer H, Jouvet M. Modification of electrical activity in cochlear nucleus during ``attention'' in unanesthetized cats.  Science . 1956;  123 331-332
    PubMedGoogle Scholar
  • 16 Sokolov Y N. Perception and the Conditioned Reflex.  Oxford: Pergmon Press; 1963
    Google Scholar
  • 17 Watson R T, Valenstein E, Heilman K M. Thalamic neglect: the possible role of the medical thalamus and nucleus reticularis thalami in behavior.  Arch Neurol . 1981;  38 501-507
    PubMedGoogle Scholar
  • 18 Moruzzi G, Magoun H W. Brainstem reticular formation and activation of the EEG.  Electroencephalogr Clin Neurophysiol . 1949;  1 455-473
    PubMedGoogle Scholar
  • 19 Bender M B. Disorders of Perception.  Springfield, IL: CC Thomas; 1952
    Google Scholar
  • 20 Denny-Brown D, Banker B Q. Amophosynthesis from left parietal lesions.  Arch Neurol Psychiatry . 1954;  71 302-313
    PubMedGoogle Scholar
  • 21 Heilman K M, Valenstein E, Watson R T. Localization of neglect. In: Kertesz A, ed. Localization in Neurology New York: Academic Press 1983: 471-492
    Google Scholar
  • 22 Heilman K M, Valenstein E. Frontal lobe neglect in man.  Neurology . 1972;  22 660-664
    PubMedGoogle Scholar
  • 23 Stein S, Volpe B T. Classical ``parietal'' neglect syndrome after subcortical right frontal lobe infarction.  Neurology . 1983;  33 797-799
    PubMedGoogle Scholar
  • 24 Watson R T, Valenstein E, Day A, Heilman K M. Posterior neocortical systems subserving awareness and neglect: neglect after superior temporal sulcus but not area 7 lesions.  Arch Neurol . 1994;  51 1014-1021
    PubMedGoogle Scholar
  • 25 Haxby J V, Grady C L, Horwitz B. Dissociation of object and spatial visual processing pathways in human extrastriate cortex.  Proc Natl Acad Sci USA . 1991;  88 1621-1625
    PubMedGoogle Scholar
  • 26 Welch K, Stuteville P. Experimental production of neglect in monkeys.  Brain . 1958;  81 341-347
    PubMedGoogle Scholar
  • 27 Watson R T, Miller B D, Heilman K M. Nonsensory neglect.  Ann Neurol . 1978;  3 505-508
    CrossrefPubMedGoogle Scholar
  • 28 Gainotti G, Messerli P, Tissot R. Qualitative analysis of unilateral and spatial neglect in relation to laterality of cerebral lesions.  J Neurol Neurosurg Psychiatry . 1972;  35 545-550
    PubMedGoogle Scholar
  • 29 Heilman K M, Van Den Abell T. Right hemispheric dominance for attention: the mechanisms underlying hemispheric asymmetries of inattention (neglect).  Neurology . 1980;  30 327-330
    CrossrefPubMedGoogle Scholar
  • 30 Pardo J V, Fox P T, Raichle M E. Localization of a human system for sustained attention by positron emission tomography.  Nature . 1991;  349 61-64
    CrossrefPubMedGoogle Scholar
  • 31 Heilman K M, Van Den Abell T. Right hemispheric dominance for mediating cerebral activation.  Neuropsychologia . 1979;  17 315-331
    CrossrefPubMedGoogle Scholar
  • 32 Heilman K M, Schwartz H D, Watson R T. Hypoarousal in patients with neglect syndrome and emotional indifference.  Neurology . 1978;  28 229-232
    PubMedGoogle Scholar
  • 33 Rossetti Y, Rode G, Pisella L. Prism adaptation to a rightward optical deviation rehabilitates left hemispatial neglect.  Nature . 1998;  395 166-169
    CrossrefPubMedGoogle Scholar
  • 34 Rubens A B. Caloric stimulation and unilateral visual neglect.  Neurology . 1985;  35 1019-1024
    PubMedGoogle Scholar
  • 35 Pizzamiglio L, Frasca R, Guariglia C, Incoccia C, Antonucci G. Effect of optokinetic stimulation in patients with visual neglect.  Cortex . 1990;  26 535-540
    PubMedGoogle Scholar
  • 36 Karnath H O. Subjective body orientation in neglect and the interactive contribution of neck muscle proprioception and vestibular stimulation.  Brain . 1994;  117 1001-1012
    PubMedGoogle Scholar
  • 37 Diller L, Weinberg J. Hemi-inattention in rehabilitation: the evolution of a rational remediation program. In: Weinstein EA, Friedland RR, eds. Advances in Neurology Vol. 18. New York: Raven Press; 1977
    Google Scholar
  • 38 Butter C M, Kirsh N L, Reeves G C. The effect of lateralized stimuli on unilateral spatial neglect following right hemisphere lesions.  Restorative Neurol Neurosci . 1990;  2 39-46
    PubMedGoogle Scholar
  • 39 Seron X, Deloche G, Coyette F. A retrospective analysis of a single case of neglect: a point of theory. In: Seron X, Deloche G, eds. Rehabilitation Hillsdale, NJ: Lawrence Erlbaum Associates; 1989
    Google Scholar
  • 40 Halligan P W, Marshall J C. Laterality of motor response in visuo-spatial neglect: a case study.  Neuropsychologia . 1989;  27 1301-1307
    CrossrefPubMedGoogle Scholar
  • 41 Robertson I H, North N. Spatio-motor cueing in unilateral neglect: the role of hemispace, hand, and motor activation.  Neuropsychologia . 1992;  30 553-563
    CrossrefPubMedGoogle Scholar
  • 42 Sprague J M. Interaction of cortex and superior colliculus in mediation of visually guided behavior in the cat.  Science . 1966;  153 1544-1547
    CrossrefPubMedGoogle Scholar
  • 43 Posner M I, Rafal R D. Cognitive theories of attention and the rehabilitation of attentional deficits. In: Meier MJ, Benton A, Diller L, eds. Neuropsychological Rehabilitation New York: Guilford Press; 1987
    Google Scholar
  • 44 Barrett A M, Crucian G P, Beversdorf D Q, Heilman K M. Paradoxical effect of monocular eye patching in attentional neglect (Abstract).  J Neurol Rehab . 1998;  12 42-43
    PubMedGoogle Scholar
  • 45 Corwin J V, Kanter S, Watson R T, Heilman K M, Valenstein E, Hashimoto A. Apomorphine has a therapeutic effect on neglect produced by unilateral dorsomedial prefrontal cortex lesions in rats.  Exp Neurol . 1986;  36 683-698
    PubMedGoogle Scholar
  • 46 Fleet W S, Valenstein E, Watson R T, Heilman K M. Dopamine agonist therapy for neglect in humans.  Neurology . 1987;  37 1765-17711
    PubMedGoogle Scholar