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DOI: 10.1055/s-2000-11113
Inhibition of Tyrosinase by Flavonoids, Stilbenes and Related 4-Substituted Resorcinols: Structure-Activity Investigations
Publication History
Publication Date:
31 December 2000 (online)
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Abstract
Several flavonoids, stilbenes and related 4-substituted resorcinols, obtained from Artocarpus incisus and other plants or synthesized, were tested for their inhibitory activity against tyrosinase. The structure-activity relationships suggested that specific natural or synthesized compounds having the 4-substituted resorcinol skeleton have potent tyrosinase inhibitory ability. Kinetic studies have indicated that specific compounds having the 4-substituted resorcinol skeleton exhibit competitive inhibition of the oxidation of DL-β-(3,4-dihydroxyphenyl)alanine (DL-DOPA) by mushroom tyrosinase. These findings could lead to the design and discovery of new tyrosinase inhibitors.
Key words
4-Substituted resorcinols - tyrosinase inhibitors - Artocarpus incisus - Moraceae - structure-activity relationship
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Dr. Ryuichiro Kondo
Department of Forest Products
Faculty of Agriculture
Kyushu University
Fukuoka, 812-8581
Japan
Email: kondo@agr.kyushu-u.ac.jp
Phone: +81-92-642-2989