Anti-obesity effects of Philadelphus tenuifolius extract via improvement of lipid metabolism in high-fat diet-induced obese mice

Philadelphus tenuifolius is a Korean native plant used for nerve tonic, diuretics and haemorrhoids. This study investigated the anti-obesity activities of an extract of the leaves of Philadelphus tenuifolius in high-fat diet- induced obese mice. Philadelphus tenuifolius treatment significantly reduced body weight, food efficiency ratio, adipose tissue mass, adipocyte size, and serum triglyceride, glucose, total cholesterol, low density lipoprotein-cholesterol and leptin levels in obese mice relative to the high-fat diet-fed mice. Furthermore, Philadelphus tenuifolius suppressed the mRNA levels of sterol regulatory element-binding protein 1c, peroxisome proliferator-activated receptor γ, C/EBPα, adipocyte fatty acid-binding protein and fatty acid synthase in white adipose tissue with increased levels of uncoupling protein 1 in brown adipose tissue of obese mice. These results suggest that Philadelphus tenuifolius ameliorated high-fat diet-induced obesity by downregulating the expression of transcription factors and lipogenic enzymes involved in lipid metabolism. Therefore, Philadelphus tenuifolius could be useful for preventing and treating obesity and its related metabolic diseases [1] [2].

Funding This work was supported by the KIOM of Korea (grant no. KSN1823312).

• References

• 1 Spieglman B.M.. et al. Cell 2001; 104: 531-543
• 2 Lee Y.S.. et al. Nutrients 2018; 10: 1204

Publication History

Article published online:
16 November 2023